Sentences with phrase «which increases the risk of disease»

These rogue genetic elements pepper the brain tissue of deceased people with the disorder and multiply in response to stressful events, such as infection during pregnancy, which increase the risk of the disease.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

UniQure, for example, has developed a drug called Glybera, which is essentially a virus that reverses the effects of LPLD, a disease that prevents people from breaking down fats and can cause increased risk of pancreatitis.

A portion of fast food usually has around double the calories to another similar food of the same size, and they have a lot of oxidized fat, which increases the risk of heart disease.

Studies have shown that among the many effects of physical abuse are depression, anxiety, cognitive and learning difficulties, even a lowering of IQ (especially verbal IQ), disordered sleep, flashbacks, loss of empathy, aggressive behavior, chronically high stress levels which can lead to chronic health effects such as high blood pressure and increased risk of cardiovascular disease, and inability to maintain relationships.

Everyday we read or hear about unhealthy foods - foods like infant formula, processed / packaged industrially made infant foods, junk foods, foods with high levels of starch, transfats, highly processed foods, which increase our risk of getting cancer, heart disease, diabetes, hypertension, obesity, and other non-communicable diseases (NCDs).

Artificial feeding increases the risk of not only childhood infections, but also of non-communicable diseases (NCDs) such as diabetes, obesity, cardiovascular disease and cancers, which are assuming epidemic proportions.

The risk status of a pregnancy was defined using a mixture of maternal International Classification of Disease (ICD) codes [19] and individual fields in the SMMIS database, and was based on a 2007 clinical guideline from the National Institute for Health and Clinical Excellence (NICE) which contained lists of medical and obstetric conditions which indicate increased risk of negative pregnancy outcomes [20].

Consumption of raw milk (which is not pasteurized and carries microbes) increases the risk of several diseases.

Overall obesity, which increases the risk of a range of diseases including type two diabetes, heart disease and nearly half of all cancers, costs the NHS an estimated # 4.2 million at present.

More than half a million ¹ people with diabetes in England are at increased risk of blindness because they have not received retinal screening2, an essential annual check which tests for eye disease (diabetic retinopathy).

Eating a lot of fruit and vegetables is a natural way of increasing vitamin C blood levels, which in the long term may contribute to reducing the risk of cardiovascular disease and early death.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

«We found that physical activity has the potential to preserve the volume of the hippocampus in those with increased risk for Alzheimer's disease, which means we can possibly delay cognitive decline and the onset of dementia symptoms in these individuals.

Several leading health bodies, including the World Health Organization, the Canadian Heart and Stroke Foundation, the American Heart Association, and the US Dietary Guidelines Advisory Committee have concluded that excess added sugar intake increases the risk not only of weight gain, but also of obesity and diabetes, which are associated with a heightened risk of cardiovascular disease, and tooth decay.

«The increases in prevalence reported herein are important because such youth with diabetes will enter adulthood with several years of disease duration, difficulty in treatment, an increased risk of early complications, and increased frequency of diabetes during reproductive years, which may further increase diabetes in the next generation,» the researchers write.

Additional analysis of UK Biobank data from 112,338 people of European ancestry revealed that a specific form of rs9349379 known as the G allele, which was present in 36 % of these individuals, was associated with an increased risk of coronary artery disease.

Dr Hashimoto said: «Hemodialysis patients are at increased risk of sudden cardiac death because they often have latent ischaemic heart disease which reduces blood flow to the heart.

Eating too many calories contributes to people becoming overweight and increases the risks of heart disease, diabetes and many cancers, which are among the leading causes of poor health and premature death.

Hypertriglyceridemia, which can increase risk of both cardiovascular disease and pancreatitis, is often caused by or exacerbated by uncontrolled diabetes or obesity.

«When your arteries are more stiff, you have higher pulse wave velocity, which increases your risk of cardiometabolic disease in the future,» says Raed.

In other words, a drop of 10 °C in the average temperature over seven days, which is common in several countries because of seasonal variations, is associated with an increased risk in being hospitalized or dying of heart failure of about 7 percent in people aged over 65 diagnosed with the disease..

A high - salt diet, which increases sodium storage in the skin, can also worsen autoimmune disease and even increase the risk of stomach cancer.

These conditions are associated with high blood sugar, which can damage the vessels that supply blood to vital organs and can also increase the risk of heart disease and stroke.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

Celiac disease, which results from a sensitivity to gluten, was associated with a 2.5-fold increased risk of neuropathy (nerve damage), according to an article published online by JAMA Neurology.

4 allele, which is known to increase risk of Alzheimer's disease, influenced the link between sleep - disordered breathing and cognition.

«These defects, which can occur after initial surgery for another defect, can increase the risk of complications and mortality in children with heart disease, so using imaging tools to quickly identify these defects can improve our care of these children,» she added.

We get heavily hyped drugs like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good cholesterol and death rates; and Flurizan, which reduced brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.

The comparison monkeys, which ate as much as they wanted, had an increased risk of disease 2.9 times that of the calorie - restricted group, and a threefold increased risk of death.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

Exposure to a group of common pesticides, called dithiocarbamates, has long been associated with an increased risk of Parkinson's disease, although the mechanism by which the compounds exert their toxicity on the brain has not been completely understood.

Strategies that might help identify which individuals have an increased risk of developing the disease are sorely needed.

With the development of early diagnostics of the disease, the question of which treatments to offer to completely healthy people with an increased risk of developing Alzheimer's becomes of key importance in the field of medicine.

Processed carbohydrates, which many Americans eat today in place of fat, may increase the risk of obesity, diabetes and heart disease more than fat does — a finding that has serious implications for new dietary guidelines expected this year.

Brazilian scientists from the D'Or Institute of Research and Education (IDOR) and the Federal University of Minas Gerais (UFMG) found that ADHD kids and their mothers are more likely to have shorter telomeres, a hallmark of cellular aging, which is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer.

The disease causes a build - up of mucus which blocks the lungs, increasing the risk of infections, and causing digestive problems.

Professor Jeremy Pearson, Associate Medical Director at the BHF, which part - funded the study, said: «By using the power of very large scale genetic studies, this research is the first to show that the known association between increased height and a lower risk of coronary heart disease is at least in part due to genetics, rather than purely down to nutrition or lifestyle factors.

«For example, migraine has been associated with obesity, avoidance of exercise, smoking and depression, all of which increase the risk of heart disease,» she said.

The study, which published today in the Journal of Investigative Dermatology, is the first to link psoriasis severity to an increased risk of death using an objective measure of disease severity — called Body Surface Area (BSA)-- rather than treatment patterns, such as whether or not a patient was receiving oral, injectable or phototherapy treatment for the condition.

So - called Western diets, which are high in fats and sugars but low in fiber, have been linked to an increased risk of inflammatory bowel diseases, weight gain, and diabetes.

There was also a strong link between autoimmune disease and heart and circulatory problems, which may explain some of the increased dementia risk.

The study, published Wednesday in the journal Nature, showed that the production of tar sands and other heavy oil — thick, highly viscous crude oil that is difficult to produce — are a major source of aerosols, a component of fine particle air pollution, which can affect regional weather patterns and increase the risk of lung and heart disease.

Women also are more likely to suffer from certain types of inflammatory and auto - immune disease, like lupus, that create an increased risk of blood clots, which, in turn, increases the risk of stroke.

However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications.

«Cutting sodium can cause other physiological changes such as increased resistance to insulin, which can set the stage for diabetes and increase the risk of death from heart disease,» Stolarz - Skrzypek says.

Night - time hypertension, which increases the risk of heart disease, stroke and death, affected 42.5 percent of women in the study.

Given the difficulty identifying pathogens that cause disease, the researchers say it's vital to understand which activities increase the risk of coral diseases, and to protect against them.

Crohn's disease — a chronic inflammatory bowel disease — is often treated with steroids, which are associated with possible serious long - term side effects such as bone thinning, loss of muscle mass, weight gain, and an increased risk of infection.