Sentences with phrase «which leads to cell death»

Sugar depletes the body of critical electrolytes, antioxidants, and minerals, which leads to cell death, muscle spasms, insulin resistance, and other health defects.

Not exact matches

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Roughly 2 % of people over age 35 have chronic glaucoma, in which fluid builds up inside the eyeball, leading to increased pressure and eventual death of cells in the optic nerve.

Even a change in temperature of + / - 5 ° C subjects the cell to a heat shock or cold shock, which can lead to cell death after a few hours.

The researchers from UC Berkeley, UC San Francisco Benioff Children's Hospital Oakland Research Institute (CHORI) and the University of Utah School of Medicine hope to re-infuse patients with the edited stem cells and alleviate symptoms of the disease, which primarily afflicts those of African descent and leads to anemia, painful blood blockages and early death.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Plaque hinders neuronal activity by gumming up synapses (spaces between cells through which chemical or electrical information is transmitted), eventually damaging nerve cell branches and leading to neuronal death.

They found that mice that had beta cells in which autophagy didn't work properly showed elevated levels of toxic IAPP, which led to the death of the beta cells.

Inflammation also erodes telomeres, the «caps» at the ends of chromosomes that protect genes from degradation, which can lead to early cell death, premature aging and even cancer.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging.

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer ceCell, may lead to new ways to trigger cell death in some types of cancer cecell death in some types of cancer cells.

These results collectively suggest that neural stem cells need MSI1 to generate enough neurons for normal brain size, but the presence of MSI1 also increases the vulnerability of these cells to Zika infection, leading to the death of the population which ultimately results in microcephaly.

«We discovered that metastasizing melanoma cells experience very high levels of oxidative stress, which leads to the death of most metastasizing cells,» said Dr. Sean Morrison, CRI Director and Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center.

This has the potential to initiate a positive feedback loop in which ROS drive further uroporphyrinogen I oxidation, leading to oxidative stress and pigment cell death.

Metastasis, the process by which cancer cells disseminate from their primary site to other parts of the body, leads to the death of most cancer patients.

Left unrepaired, these DNA lesions could lead to induction of senescence, cell death or mutations, which could be responsible for the development of cancer, neurodegeneration and several other diseases.

Schindler said she is specifically interested in research being done on the amyloid protein, which is believed to cause plaques in the brain which lead to the death of nerve cells that cause dementia.

Remarkably, blood CD4 T cells are resistant to this death pathway, in part because the cells are in a deeper state of rest, meaning the virus is unable to infect them completely, which prevents the onset of the chain of events that leads to pyroptosis.

Chromosomal instability (CIN) often results in aneuploidy, which compromises cell fitness and leads to cell death.

Cytoadhesion of P. falciparum in the brain leads to a large number of deaths each year and is a consequence of exported parasite proteins, some of which modify the erythrocyte cytoskeleton while others such as PfEMP1 project onto the erythrocyte surface where they bind to endothelial cells.

Neurons might literally be overexcited by incoming chemical messages, which could lead to long - term misfiring and even death of these irreplaceable cells.

Once formed, these highly reactive radicals can start a chain reaction — like dominoes — that leads to poor cell function or even cell death, which can lead to ageing.

The process of oxidation releases free radicals, which can trigger chain reactions leading to the death or damage of cells.

Studies have shown that excess iodine causes thyroid injury by generating reactive oxygen species, which lead to premature damage and programmed cell death in thyroid tissues.

The result is an intense inflammatory reaction in the tissues where the virus - infected cells reside, which causes damage to multiple systems at once and ultimately leads to death.

From there, it travels up to the brain, where it attacks the cells, which can lead to certain death for dogs.

Any time the seizures are too frequent they can cause a process call «kindling» in which further (non-epileptic) brain cells are affected adversely leading to the next set of seizures occurring even sooner or lasting longer.8 Eventually some dogs have very frequent clusters of seizures happening multiple time in one day, or go into a continuous seizure (status epilepticus) which is life threatening and can lead to permanent brain damage or death.