Sentences with phrase «which of these cell lines»

«With our sequencing and transcriptional data, we can figure out which of these cell lines most closely match the human tumors.

Not exact matches

Most of the action is coordinated by white blood cells, which direct the lines of attack like football coaches, churning out antibodies that target the opponent for destruction.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

RU - 486, which is not for sale in the U.S., blocks cells in the uterus from receiving the natural hormone progesterone, the function of which is to prepare the lining of the uterus to receive and sustain a fertilized egg.

Nevertheless, our first intuition — which sensed that a line ought to be drawn prohibiting alterations of term cells — is, I think, a sound one.

Where is the clear line in a progression from (1) using animal insulin to treat diabetes, to (2) using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ cells which would otherwise have transmitted the disease to one's offspring?

Eating probiotic rich foods (or taking a high - quality supplement in which the bacteria are still alive) improves our immune systems, helps lessen the gaps between the cells that line our intestinal walls (gaps that are not supposed to be there), and restores proper balance of microflora in the intestine.

Our bodies then use these essential nutrients to rebuild cells and particularly the lining of our intestine — which prevents those food sensitivities that seem to be on the rise these days.

Before we established in - house human taste cell (HTC) technologies, it was not possible to use human tongue - derived cells as a model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.

Oligosaccharides, which are simple chains of sugars, often contain domains that resemble the binding sites through which bacteria gain entry into the cells lining the intestinal tract.

Some of you may remember my 2011 Lunch Tray post («Social Media and Social Stigma on the Lunch Line «-RRB- in which I reported that students in HISD were taking cell phone pictures of kids standing in the federally reimbursed school meal line, then sharing these photos on social media with disparaging commeLine «-RRB- in which I reported that students in HISD were taking cell phone pictures of kids standing in the federally reimbursed school meal line, then sharing these photos on social media with disparaging commeline, then sharing these photos on social media with disparaging comments.

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

The scientists also generated a panel of (reconstructed) ancestral and existing TRIM5 genes (19 total), expressed them in cultured cell lines, and exposed the cells to 16 different retroviruses (lentiviruses and others) to see which TRIM5 versions conferred resistance to which viruses.

The cells, which lined the pores of the scaffold, were regularly fed with streams of nutrients, growth factors and oxygen in a bioreactor.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

In August, the team reported another step toward that goal: The researchers had raised not just cell lines that were free of the retroviruses, but 15 live piglets in which problematic retroviruses had been eliminated (SN: 9/2/17, p. 15).

One perplexing problem, however, is that three out of 13 of the iPS cell lines created by Hochedlinger's team had a complete extra set of chromosomes, which has not been seen with iPS cells made using retroviruses.

Compared with unheated mice, the animals with the faux fever had twice as many white blood cells migrating out of the blood vessels and into the lymph tissue that lines the skin and gut, which is where they need to be to attack incoming pathogens.

CMRB has two parts: the Cell Line Bank of Barcelona, which generates and maintains embryonic stem cell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative medicCell Line Bank of Barcelona, which generates and maintains embryonic stem cell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative mediccell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative medicine.

As those cells proliferated in laboratory dishes, the bits of human DNA were also copied, creating cell lines, each of which had a different fragment.

Analyzing data from thousands of cancer lines and tumors, the researchers found that those demonstrating resistance to proteasome inhibitor drugs were marked by suppressed expression of one or more of the cells» proteasome cap subunits (which are a subsets of the larger proteasome).

DNA from the cell nucleus, which includes both maternal and paternal lines, tells a different story: The two types of elephants are in fact separate species, leading recently to a proposed relisting of the forest elephant as Loxodonta cyclotis.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

«I got most excited about it when George brought his idea of virus - resistant mammalian cells on the table, and the idea of an ultrasafe cell line, which could be a relatively short - term win,» Boeke says.

Hamilton announced the newest organ - on - chip innovation, which recreates an intestinal lining using patient - derived stem cells, created through a partnership between Emulate and Cedars - Sinai Board of Governors Regenerative Medicine Institute.

Researchers are also experimenting with another form of immunotherapy called adoptive cell transfer, which harvests and then reintroduces patients» tumor - infiltrating lymphocytes — cells with anti-tumor capabilities that dig deep behind enemy lines.

As other researchers asked for samples, the cells replicated, grew, and proliferated so wildly that they often took over and wiped out cell lines of any kind with which they happened to come in contact.

Dr. Jiang found that LPCAT3 deficiency significantly reduces polyunsaturated PC levels in the plasma membrane of the cells that line the intestines, which in turn reduces lipid absorption and decreases levels of lipids (cholesterol, triglyceride, and phospholipid) in circulation.

T cells, along with B cells and others, comprise the adaptive arm of the immune system, the body's second line of defense which quickly attacks and «remembers» specific pathogens.

Until recently, Ain was renowned for a highly prized repository of 18 immortal cancer cell lines, which he developed by harvesting tissue from his patients» tumors after removal, carefully culturing them to everlasting life in vials.

He says that he is ready to ship the cloned ES cell lines to several labs that have requested them as soon as the Oregon institutional review board signs off on the transfers, which could happen in a matter of days.

Once the inflammatory process has been initiated, neutrophils within the joint space release interleukin - 1, which induces cells lining the joint space to produce chemoattractants called chemokines that further facilitate the movement of neutrophils into the joint space.

In their latest study, Guarente and his colleagues decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Banik cautions that neither of the contrast agents has yet been tested on animals injected with breast cancer cell lines, which he calls an important step to take.

The development of tailored cell lines is also possible, in which case nutritional characteristics can be developed according to need.

«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.

The final guidelines on research with human embryonic stem cells issued on Monday by the National Institutes of Health set out criteria for determining which ES cell lines can be used in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.

The researchers then differentiated the iPS cells into endothelial cells, which line the interior of the heart and blood vessels, before transplantation.

Most biologists typically recognize three official branches of life: the eukaryotes, which are organisms whose cells have a nucleus; bacteria, the single - celled organisms that may or may not possess a nucleus; and archaea, an ancient line of microbes without nuclei that may make up as much as a third of all life on Earth (See «Will the Methane Bubble Burst?»

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.

Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z / 3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes.

As a result, many of the studies published up to now describe only two or three patient stem cell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wcell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wCell Research Group (NCRCRG) program, which supported this work.

Using a powerful imaging technique that allowed the scientists to track the presence and movement of parasites in living tissues, the researchers found that Toxoplasma infects the brain's endothelial cells, which line blood vessels, reproduces inside of them, and then moves on to invade the central nervous system.

The finding potentially paves the way for scores of labs to generate new stem cell lines without cloned embryos, which had long been considered the only realistic way of making human stem cells in the short run.