It is responsible for most anabolic reactions, in
which precursor molecules are joined together into larger molecules.
Not exact matches
In 2016, Cornelia Meinert of the University Nice Sophia Antipolis in France and colleagues showed that irradiated ice forms a cornucopia of
molecules essential to life, including ribose, the backbone of RNA,
which may have been a
precursor to DNA (SN: 4/30/16, p. 18).
During synthesis, GDF8 or myostatin, is made as a
precursor which remains in a dormant state with half of the
molecule holding the section of GDF8 responsible for signaling inactive, says Thompson.
They also found that distant metastases and their
precursors processed glucose through a growth - promoting series of metabolic reactions called the pentose phosphate pathway,
which burns (or oxidizes) glucose - derived
molecules into building blocks for tumors.
To demonstrate this versatility, the researchers tested their approach with a metabolic pathway that produces a
molecule called shikimate,
which is a
precursor to several different amino acids and is also an ingredient in some drugs including the influenza drug Tamiflu.
Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid
precursor protein, a
molecule that generates amyloid beta,
which aggregate and form plaques in the brains of Alzheimer's patients.
Dopamine, a
molecule crucial for signaling between neurons, can not cross this barrier,
which is why its chemical
precursor, L - dopa, is used instead to treat Parkinson's disease.
This forms one of the
precursor molecules,
which is lead plus long oleate ligands, and a byproduct of water.
To produce triangulene, the team began with a
precursor molecule called dihydrotriangulene,
which lacks the reactive unpaired electrons.
Then, by systematically applying a range of monochloramine and dichloramine doses to pharmaceutical
precursors, they were able to determine
which molecule was the root cause of NDMA formation.
But unlike DNA,
which has a single job, RNA can play many parts — including acting as a
precursor for small
molecules that block the activity of genes.
They were looking for a site with a venting process that produces a lot of hydrogen because of the potential it holds for the chemical, or abiotic, creation of organic
molecules like methane — possible
precursors to the prebiotic compounds from
which life on Earth emerged.
Previous studies have revealed that exercise induces the production of irisin and its
precursor molecule, FNDC5 (fibronectin - type III domain - containing 5) protein,
which convert white fat tissue into beneficial, calorie - burning brown fat.
The initial work identified the
precursor to GS - 5734, a small -
molecule antiviral agent,
which led to the effort by Gilead and USAMRIID to further refine, develop and evaluate the compound.
Enceladus Life Finder,
which would fly through plumes multiple times to collect and characterize the
molecules that are there — particularly complex organic compounds that could indicate
precursors of life.
«We knew from our work in Drosophila that Zucchini functions at the initial processing step, in
which long piRNA
precursor molecules are cut into shorter fragments,» explains Haase.
However, one mass feature present at significant levels in bsl1 - 1 inflorescences, but not in the other samples, matched the exact mass of a pregnane ring - containing
molecule,
which is predicted as a cleavage product of 3 - β - ketone derivatives of BR and sterol
precursors 5 - dehydroepisterol, 5 - dehydroavenasterol, 7 - dehydrodesmosterol, and 7 - dehydrocholesterol (Supplemental Figure 6).
Another novel biomarker is proneurotensin, the
precursor molecule of neurotensin,
which is peripherally released from the endocrine - like N - cells of the small intestine after fat intake (49).
«The great thing is, we can chemically tag the DNA
precursors with a fluorescent
molecule,
which means when it is attached to the viral genome it will fluoresce, allowing us to detect it and visualize how it infects a cell.»
As a postdoctoral fellow in Dr. Cori Bargmann's lab at the Rockefeller University, she showed that the nematode C. elegans produces a neuropeptide that is an evolutionary
precursor of the mammalian peptides vasopressin and oxytocin, and mapped a neural circuit by
which this
molecule, nematocin, modulates mating behavior.
Consuming creatine increases the supply of the
precursor to ATP, a high - energy
molecule which actually gives you the energy to go through each rep you perform.
Eventually, more debris and enzymes spill into the joint fluid and destroy
molecules called glycosaminoglycan and hyaluronate
which are important
precursors that form the cartilage proteoglycans.
Glucosamine is well - regarded as one of the
precursor molecules of glycosaminoglycans
which are, in turn, very important component of cartilage, the tissue that makes up the joints.
In Amyris's process, sugarcane stalks are crushed and the juices are then placed in 5,000 - liter fermenters with the company's engineered yeast,
which makes a diesel -
precursor molecule.