Sentences with phrase «which regulate cell growth»

So Hoffman is now looking for leads among genes controlling the production of molecules called growth factors, which regulate cell growth and division.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

Not exact matches

A third influential gene was ARMS / KIDINS220, which codes for a protein that regulates the growth of nerve cells.

About ten years ago, research results showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

AMPK responds to energy deficits in the cell by down - regulating energy consuming processes, which are often associated with cell growth, and up - regulating energy producing processes.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

Most group 3 medulloblastoma tumors feature excessive levels of the c - MYC protein, which helps to regulate cell growth.

Caption: Scientists have proven that these nanomaterials may regulate the formation of synapses, specialized structures through which the nerve cells communicate, and modulate biological mechanisms, such as the growth of neurons, as part of a self - regulating process.

The subpopulation that failed to produce Wnt1 contributed to tumor growth with a mutation in a gene called HRas, which regulates cell division.

Scientists have proven that these nanomaterials may regulate the formation of synapses, specialized structures through which the nerve cells communicate, and modulate biological mechanisms, such as the growth of neurons, as part of a self - regulating process.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Liron Bar - Peled, Grand Prize winner and Cell & Developmental Biology category winner, told about his research on the enzyme mTORC1 which regulates eukaryotic cell growth and is deregulated in some common cancers and diabeCell & Developmental Biology category winner, told about his research on the enzyme mTORC1 which regulates eukaryotic cell growth and is deregulated in some common cancers and diabecell growth and is deregulated in some common cancers and diabetes.

Researchers identify the molecular structure of the GATOR1 protein complex, which regulates growth signals in human cells, using cryo - electron microscopy.

The sweet melon contains beta carotene, or vitamin A, which is believed to regulate the growth of skin cells on your scalp and sebum in the skin's outer layer, Dr. Zeichner says.

Proteins are necessary for cell division which is vital in healing and growth, and proteins in the form of hormones and enzymes regulate chemical reactions in the body.

Glutamine is the most abundant amino acid in human muscle, directly regulating both the production and wearing - down of protein and immune cell activity.Glutamine is converted into glutamate, which can directly enhance growth hormone secretion.

Pterostilbene limits the expression of the mTOR signaling pathway, which helps to regulate the growth, survival and proliferation of cells.

And it is this thermogenic ingredient that provides the home remedy because it can inhibit proteins called PPARy and LXRa — both of which regulate genes involved in adipose cell growth.

They help regulate the Autonomic Nervous System (which controls the automatic body functions like heart rate, blood pressure, digestion, muscle contraction and relaxation), nutrient transfer across cell membranes, and the regulation of tissue growth.

mTOR is a biological pathway in the body which plays an important role in regulating cell growth and proliferation that may also have an influence over cancer growth (6).