Over the years, he's seen a number of ways in
which replication studies can go wrong in career terms.
Not exact matches
The tools were
studied by Dr. Harmand and her colleague Hélène Roche — world experts in lithic analysis, the
study of stone artifacts from the various Stone Age periods in
which they were made — to interpret physical features and reconstruct the manufacturing techniques used at the prehistoric site, including experimental
replication of the tools.
Our independent scientific advisory board — all members of
which are leaders in their fields as well as advocates on the reproducibility problem — selects
studies for
replication.
It also undergoes cell division by first creating copies of chromosomes like most human cells and has a very fast
replication cycle, all of
which facilitated the
study.
For the new
study, Geisbert and his colleagues used snippets of so - called small interfering RNAs (siRNA),
which can tinker with a virus's
replication.
One of the paper's co-authors, Hugh Willison, who
studies GBS at the University of Glasgow in Scotland, says it's possible that something more subtle is happening: Like other viruses, the one that causes Zika hijacks a cell's own
replication machinery to make new copies of itself,
which then break out of the dying cell and infect neighboring cells.
In case - control and
replication studies involving a total of some 45,000 CM and BCC patients and control subjects from Iceland, Sweden, Spain, Hungary, Romania and Slovakia, carrying one set of the ASIP variants —
which 15 % of the population does — was shown to correspond to a 45 % increase in risk of CM and 33 % increase in risk of BCC compared to non-carriers.
The biological
replication in our
study is in the form of many individual wasps that were pooled prior to sequencing,
which means we have only modest power to detect differential expression.
As long as research data is obtained through hypotheses posed in testable terms and nested in a body of established theory; as long as the data collection and analytical methods permit direct investigation of the question; and as long as the
study results are open to
replication and professional scrutiny, we will have a professional body of research on
which to base reform efforts.
«As long as
study results are open to
replication and professional scrutiny, we will have a professional body of research on
which to base reform efforts.»
Finally, Steven Rouk (Mercy For Animals) will conduct a
replication and extension of their 2015
study examining
which characteristics of social media posts are associated with the highest number of impressions.
Therefore, approaches such as immunomodulation,
which could result in sustained
replication and subsequently increased oncolysis, have not been
studied.
Its equally «traditional» to point out a flaw in someone's methodology
which may invalidate a
study without doing a full
replication.
The low response rate obtained in the present
study limits the confidence with
which one can generalize the results, and there is a clear need for
replication.
Initially,
replication problems of case - control
studies were often attributed to population stratification (case and control groups originating from genetically distinct populations) and to multiple testing without appropriate corrections,
which could result in spurious associations.
Limitations exist with respect to
replication of
studies, generalisability, predictions of
which children will benefit and
which treatment components are effective, and long term effects of therapy.
We insist that these results have to be cautiously interpreted until they are confirmed in a
replication study, in
which an external observer collects the data about the child.