Not exact matches
The UI study,
which was published March 28 online in the journal Molecular Psychiatry, adds to the accumulating evidence, including recent human studies from Harvard University, that suggests cerebellar stimulation might help improve cognitive problems in
patients with
schizophrenia.
Unlike «big data» genetic studies,
which have loosely linked hundreds of genetic changes to
schizophrenia but can not explain varying symptoms, the new study revealed distinct disease versions that may affect large slices of
patients and enable precision treatment design, say the authors.
When, for example, subjects were asked 20 times in succession to estimate the duration for
which a square — displayed for exactly one second in each case — appeared on the screen, the estimates given by
patients with
schizophrenia exhibited a much higher level of variability than those of the control group.
Indeed, by limiting the debate to whether PIER does or doesn't prevent
schizophrenia, it's possible to miss a larger point, namely, that most of the
patients enter the program because they are in serious need of help, without
which they could succumb to psychosis, violence, or suicide.
Already this has shown that
schizophrenia patients have particular problems noticing what has changed in a previously learned scene in
which an object has been moved, but do better at recognising when the object has been replaced with something else.
Researchers might generate personalized brain organoids from the reprogrammed skin cells of individuals with, say,
schizophrenia and test
which medications work best for
patients with particular genetic profiles of the illness.
«Cold water in the left ear significantly increased
patients» insight and awareness of their
schizophrenia,
which we measured 30 minutes after the test, compared with the sham or placebo treatment using room temperature water,» says Dr. Gerretsen.
Alterations in the genetic coding for a nerve cell receptor,
which detects a chemical signal that is key to behavioral change, could point the way to designing therapies most effective for
patients suffering from
schizophrenia, drug addiction and other mental illnesses.
Researchers found that the gene XIST,
which is responsible for inactivating one of the two copies of the X chromosome in cells that store genetic material, works overtime in female
patients with mental illnesses, such as bipolar disorder, major depression and
schizophrenia.
A year earlier, researchers at the University of Montreal identified a Shank3 mutation in
patients suffering from
schizophrenia,
which is characterized by hallucinations, cognitive impairment, and abnormal social behavior.
«This is the first demonstration of the profile of angiogenic molecules expression using neural stem cells derived from
patients with
schizophrenia,
which shows they have a less angiogenic profile when compared to controls,» says Palma.
Dr. Rudolph's group is developing mouse lines that carry mutations found in
patients with
schizophrenia — specifically copy number variations, in
which segments of DNA are either duplicated or deleted.
Clozaril (clozapine) is indicated for the treatment of severe
schizophrenia in
patients for
which standard therapy has not been effective and can affect a
patient's white blood cell count and neutrophil count.
A study investigating differences in HRV in BD,
schizophrenia and healthy controls was performed in 2015 by Quintana et al9,
which included 33
patients with BD, 47
patients with
schizophrenia and 212 healthy controls; however, no information is given about the current mental state of the BD group
patients.
Any of our mental health practices
which may have misdiagnosed and mistreated grief as depression, spiritual experience as psychosis or
schizophrenia, and political resistance as intransigent or psychopathic behaviours, mistaking the asserting of cultural identity, and defiance for the disturbing behaviours of difficult
patients.
Because an improvement of 50 % or more in psychotic symptoms represents such an important clinical change in
patients with chronic
schizophrenia a logistic regression was performed to investigate
which variables contributed to this improvement.
Kavanagh39 reported the median proportion of high EE families in their meta - analysis as 54 % with a range from 23 % to 77 %, whereas figures are typically lower than 40 % in staff -
patient studies.12, 23,24,27,28,40 — 42 It may be the case that psychiatric staff have both more experience and training in managing
patients» problems than relatives
which may be protective factors against the development of high EE.43 In support of this hypothesis, an early study
which involved interviewing nurses about how they cope with
patients» symptoms of
schizophrenia found that more experienced senior staff used a greater number and range of coping strategies than less experienced staff.43 High EE ratings in staff -
patient studies are also almost exclusively based on the presence of critical comments with infrequent hostility and very little evidence of EOI.