«We're definitely encouraged by these results, but we need to optimize the length of treatments, identify
which subgroups of patients may benefit most, and determine if this approach works in patients who have nonsomatic forms of the condition that can't be modulated by head and neck maneuvers,» Shore said.
Not exact matches
This imaging approach could also, in the future, help better define
which patients with autoimmunity will likely progress to diabetes and classify
subgroups of patients who might benefit from different therapeutic strategies.
However, a pre-specified examination
of the study's secondary endpoints,
which included the rate
of heart attacks, revealed that
patients who received the methylprednisolone faced a 15 percent greater risk
of death or heart attack and a 21 percent greater risk
of heart attack alone, a pattern that was consistent across all
subgroups.
The authors conclude that FL118 - based therapy may be beneficial for a
subgroup of cancer
patients with tumors such as chronic lymphocytic leukemia and melanomas, in
which MdmX overexpression confers treatment resistance.
One
of the most exciting recent advances in clinical cancer research was the discovery that this
subgroup of patients respond — sometimes dramatically — to a new class
of drugs targeting the MAPK pathway through
which BRAF signals.
He added: «The only positive and continuous result was in the
subgroup of patients who took more exercise,
which means regular exercise at least twice a week, plus the wine consumption.
There were similar results across prespecified
subgroups of patients including analyses
of PD - L1 expression,
which showed hazard ratios in favor
of nivolumab.
Not all lung cancers are linked to ALK mutations, so the drug crizotinib,
which inhibits the mutant enzyme, is prescribed only for that small
subgroup of lung cancer
patients.
The study was developed as an extension
of the GAIT (Glucosamine / Chondroitin Arthritis Intervention Trial) study,
which showed that the combination
of glucosamine hydrochloride (1,500 mg / day) and chondroitin sulfate (1,200 mg / day) was effective in a moderate to severe
subgroup of patients.