Sentences with phrase «which subsequent development»

In the early childhood years, children develop the foundation upon which subsequent development in all domains of learning is built.

This, however, does not affect the crucial fact, from which the subsequent development of Israel's religion proceeds, that the distinctive faith of the Hebrews began with the covenant between them and a deity new to their allegiance.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

I will, however, take two essays I published in the 1970s (both included in Beyond Belief) as intellectual benchmarks with respect to which I will measure changes, developments and continuities in the subsequent years.

McGrath is aware of the risk of slipping into Deism - with a creator sitting back and detachedly watching his creation unfurl - hence, his emphasis on the importance of a Trinitarian approach, in which God not only intervenes in the subsequent development of His Creation, but in which the whole Christian economy of salvation is worked out.

And the story of subsequent Jewish political development is to be traced, not primarily in the hierarchy of restored Palestinian Judaism and the arrogance of the House of Hasmon, but in the popular assembly with its ruling elders which continued, with local adaptations and variations, it is true, but in essential uniformity, right through the long centuries of the dispersion and into our own times.

In subsequent passage, however, he adds that it is possible to conceive «an infinite number of degrees» between matter and fully developed spirit: «Each of these successive degrees, which measures a growing intensity of life, corresponds to a higher tension of duration and is made manifest externally by a greater development of the sensory - motor system» (MM 296, Cf. also MM 332).

Some studies do link the use of marijuana with premature birth, lower birth weight and even compromised neurological development which has subsequent behavior issues in the children.

The subsequent developments in the enemy combatant cases (some of which arose collaterally in the criminal trial of Padilla), haven't really change the relevant law.

[3] This shouldn't be terribly surprising given the Republican preference for development - heavy defense spending; the ramp - up of defense spending under Bush following the September 11 attacks and subsequent wind - down under Obama; and partisan differences over certain forms of applied research, which some Republicans believe is better left to the private sector.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

In a related study published recently in the journal Child Abuse and Neglect, Valentino found that maltreating parents, many of whom had experienced childhood trauma, could successfully be taught to use more elaborative and emotion - rich reminiscing with their preschool - aged children, which has been linked to a children's subsequent cognitive abilities in a number of areas including memory, language and literacy development.

This development, Rothschild observes, helped foster subsequent political relationships, which took hold, in part, at the United Nations.

The nerve cells of the central nervous system (CNS), which is composed of the spinal cord, the brain, and the retina, must be supplied with sufficient oxygen and nutrients through the blood vessel system during development and their subsequent function.

The degree to which this innate tendency to appreciate the taste of salt is modified by subsequent experience is a research area ripe for further investigation, particularly because high salt intake has been implicated in the development and / or maintenance of elevated blood pressure.

Scientists also hope to gain crucial insights into autism's risk factors from several large new studies, including the federally funded Early Autism Risk Longitudinal Investigation, which will enroll 1,200 mothers of autistic children at the start of a subsequent pregnancy and then track the newborn child's first three years of development.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

For their outstanding contribution to research into the properties of clad optical fibres and their subsequent successful development leading to the commercial production of such fibres which are playing an increasing role into the field of communications.

This suggests that gut bacteria is closely tied to early brain development and subsequent behavior, which is what Dr. Campbell has found as well.

Needless to say, this development has a negative effect on their subsequent screen performance which in turn frustrates Sam when he can no longer coax the same chemistry out of his leading man and woman.

In subsequent sections we'll discuss the role of gamification and augmented reality and virtuality in eLearning (which doubtless increase the «fun» quotient for users), but a system that is actually appealing and engaging for users will ultimately let them learn better and faster and let Learning and Development professionals rest easier that their learners are acquiring knowledge at a good pace.

The extensive review, and its subsequent presentation to 160 governments, led to the development of a multiyear Education Strategy published by UNHCR, which Dryden - Peterson helped to draft.

Readium.js and the core JavaScript modules Readium.js shares with Readium SDK were developed subsequent to the initial development of Readium Chrome Extension, which is not (as of September 2013) «synched up» with the new more modular architecture for these components.

In addition, consistently administering vaccines into distal limb sites results in the administration of subsequent vaccine doses into the same site, which may increase risk for tumor development.

Pyriproxyfen, the second active ingredient in Advantage II, prevents flea eggs from hatching, which in turn prevents the development of all subsequent flea life stages and thus ends the flea lifecycle.

We also provided timely funding which led to the discovery of the cause, and subsequent vaccine development for Potomac horse fever.

Cerebellar volume is potentially a key factor in determining the degree of obstruction and interference in normal CSF flow through the foramen magnum, which disposes dogs to the subsequent development of SM.

The controversy surrounding Team Bondi's treatment of their staff and subsequent liquidation can't have helped, but in a chat with IGN, Rockstar Jeronimo Barrera, VP of Product Development, revealed the delay boiled down to the studio wanting to finish all the console DLC first before beginning work on the PC port, which they didn't want to rush.

[1] The exhibition was a «seminal» [2] London group show which was significant in the subsequent development of the Young British Artists.

In view of the above, it would be advantageous to devise an article structure of (sub) sections, which could be be something like origin, influences / teachers, then the sub genres, such as large flat areas, stripes, painterly application or whatever, then subsequent development.

Reinterpreting Malevič, Tatlin, El Lisitzky and other key exponents of these movements allowed Pardi to take the still vital elements of these artistic directions and become one of the most active and qualified representatives of the history of contemporary painting and sculpture.This extensive retrospective illustrates the development of Pardi's explorations at every phase, from the first depictions of architectural interiors and exteriors of the 1960s, such as the Environments and Hanging Gardens, to subsequent works from the 1970s, which he named Architectures.The series Diagonals are from the early 1980s and consist of straight lines whose tight rhythm oscillates between black and white to a search for new montages and movements.

The ambitious scale of this exhibition introduces various perspectives on the movement and invites a new understanding of a period which influenced the artistic developments of the subsequent half century.

Ranging across Jasper Johns's entire career — from his breakthrough paintings of the 1950's, which paved the way for the subsequent development of pop art and minimalism, Jasper Johns has had numerous museum retrospectives throughout his career, including paintings, drawings, prints as well as a host of other themes; recent highlights include the landmark 1997 exhibition» «Jasper Johns: A Retrospective» at the Museum of Modern Art, curated by Kirk Varnedoe and the breathtaking 2008 «Jasper Johns: Gray» at the Art Institute of Chicago and The Metropolitan Museum of Art.

Seeking a means of sharing his ground - breaking work, he invented the zoopraxiscope, a method of projecting animated versions of his photographs as short moving sequences, which anticipated subsequent developments in the history of cinema.

Ranging across Johns's entire career — from his breakthrough paintings of the 1950s, which paved the way for the subsequent development of Pop art and Minimalism, to his most recent work — the survey offers a rich overview of the visual and philosophical inquiries central to Johns's practice and illuminates his enormous impact on artistic developments following Abstract Expressionism.

A particular highlight this year will be the ongoing examination into the social, political and economic landscape that shaped ROSC and its subsequent impact on contemporary art developments in Ireland, which will culminate in a major symposium in November 2017, our ongoing provision of programmes for people living with dementia through the AZURE initiative and the launch of a new digital digest that will develop new content about our programmes, giving people new ways to find out more about the work, and to personally connect with art and artists at IMMA.

The fight over the formal proceedings, which were bound to be underwhelming, distracts from some significant developments that I'll be covering in subsequent posts.

I think it is time for a general update due to subsequent developments (especially the current 2 year global cooling trend and a quieter sun with cooling oceans after an 8 year temperature plateau which tends to show that my point about solar and oceanic influences on global temperatures has some merit) and the fact that I can make the essential points more simply by condensing them into a series of bullet points as follows:

«A general update due to subsequent developments (especially the current 2 year global cooling trend and a quieter sun with cooling oceans after an 8 year temperature plateau which tends to show that my point about solar and oceanic influences on global temperatures has some merit)» - Stephen Wild...

I am not aware of any subsequent statutory, regulatory or case law developments in India which have changed this situation, but that kind of tweak of IT Act regulations in India wouldn't necessary make headlines outside of the local IT industry press coverage in obscure trade journals.

The development took place over decades, beginning with the Supreme Court's 1979 decision in Monsanto Company v Commissioner of Patents, which articulated the principle of sound prediction and prohibited post-filing evidence, and by subsequent decisions over the next 23 years, including the Supreme Court's articulation of the utility test in Consolboard Inc v MacMillan Bloedel (Sask) Ltd, and a later decision in Apotex Inc v Wellcome Foundation Ltd, which clarified the disclosure requirement.

The development follows a sharp recovery from the Jan. 17 low of $ 1,343, which witnessed a follow - through buying in the subsequent days.

In Chapter 12 Dawkins is making a point about the development of Evolutionarily Stable Strategies (ESS) in a social context, and the role of game theory in illuminating the development of cooperation and selfishness, in particular a game called the «prisoner's dilemma» which highlights the development and subsequent stability of cooperation and selfish strategies for how we socially relate to each other.

Participants will be able to identify the ways in which complex trauma and childhood development interact to determine adaptive strategies for the child and subsequent symptoms.

The effect of the nurses and paraprofessionals on responsive mother - child interaction indicates that the program was operating as intended in helping parents provide more sensitive and responsive care for their children, which is thought to promote secure attachment and healthy emotional and behavioral development.49 The reductions in subsequent pregnancies and increases in interpregnancy intervals are particularly important as short interpregnancy intervals increase the risk of child maltreatment (including infant homicide among teen parents) 50 and compromise families» economic self - sufficiency.51

It is also the foundation upon which subsequent learning and development depends.

Consistent early relationships and experiences are the foundation upon which all subsequent emotional development rests... [¶] Consistency in relationships for infants is achieved through attachment — the formation of an enduring emotional bond with a primary or small number of stable, responsive, and sensitive caregivers.

Consistent early relationships and experiences are the foundation upon which all subsequent emotional development rests...