Sentences with phrase «which subunit»

«From this we observed which subunit within TORC2 was obstructing the rapamycin - binding site on TOR.»

People with familial vibratory urticaria produce a mutated ADGRE2 protein in which this subunit interaction is less stable, the investigators found.

But they haven't been able to nail down which subunits are the most important for addiction.

Not exact matches

The DNA molecule is an extremely long chain of strictly ordered subunits, a length of several hundred to several thousand of which is called a gene.

But the point is that Faith and Order, which historically was the premier enterprise of the council, ended up as a subunit of a unit.

Three fairly well - defined subunits appear, which at one time were probably three separate cycles of stories.

The subunits center in (1) Abraham and Isaac, 12 - 26; (2) Jacob (and Esau), 27 - 36; (3) Joseph, 37 - 50 (excepting 38 which deals with Judah and Tamar).

TERT is a subunit of the enzyme telomerase, which is a widely known enzyme because it has been touted as an anti-aging enzyme.

The appearance of the variant after starch - gel electrophoresis of the hemolysates supports the concept that the lactic dehydrogenase isozymes are determined by the interaction of two subunits which are under separate genetic control.

It contains five metal clusters of which clusters B, B ′, and a subunit - bridging, surface - exposed cluster D are cubane - type [4Fe - 4S] clusters.

Domain II of EF - P interacts with the ribosomal protein L1, which results in the largest movement of the L1 stalk that has been observed in the absence of ratcheting of the ribosomal subunits.

Furthermore, NCF2, which encodes another subunit of NOX2, is associated with SLE risk in European Americans.

This was important because NCF1, which encodes a subunit of NOX2, is thought to be related to SLE due to its role in activating the phagocytic complex NOX2.

Analyzing data from thousands of cancer lines and tumors, the researchers found that those demonstrating resistance to proteasome inhibitor drugs were marked by suppressed expression of one or more of the cells» proteasome cap subunits (which are a subsets of the larger proteasome).

Building from two subunits, alpha and beta tubulin, this protein assembles into microtubules that play a vital role inside cells — giving structure, pushing or pulling other things around, or providing a track on which other molecules can pull themselves along.

The channel, which consists of two identical subunits, is shown in the center.

The research suggests that the ADGRE2 subunit interaction plays a key role in the mast cell response to certain physical stimuli, which could have implications for other diseases in which mast cells are involved.

The gene, called gyrase B, codes for a variable subunit of the DNA gyrase protein, which helps DNA coil and uncoil.

In ESCs, SSUP subunits are up - regulated which enhances their translation rate and supports the interconnected regulatory network which controls pluripotency.

The simulations demonstrated that the critical factor is particle density — in other words, the total concentration of subunits in the system: In a system in which the particle density is low, opportunities for interaction are few, and individual filaments are widely separated.

The NMDA receptor makeup includes receptor «subunits» — all of which have distinct properties and act in distinct ways in the brain, sometimes causing neurological problems.

New Cambridge research provides fresh and unexpected insight into the structure of sodium channels and, specifically, one of its components — β - subunit molecules — which are responsible for «fine - tuning» the activity of the channel.

Still, Zuker was adamant: Knock out either of the two subunits on the protein receptor he identified and laboratory mice lose all sense of sweet, regardless of which compounds they're given.

The new wing architecture, which could greatly simplify the manufacturing process and reduce fuel consumption by improving the wing's aerodynamics, as well as improving its agility, is based on a system of tiny, lightweight subunits that could be assembled by a team of small specialized robots, and ultimately could be used to build the entire airframe.

Scientists studied the gram - negative bacteria E.coli, in which the beta - barrel assembly machinery contains five subunits — known as BamA, BamB, BamC, BamD and BamE.

That gene encodes a protein called BAF 180, which is a subunit of the PBAF subtype of the SWI / SNF chromatin remodeling complex.

The subunit BamA is located in the outer membrane and exposed to the outer side of the bacteria, which provides a great target for new drugs.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

This block is caused by mutations of the gene encoding the γc cytokine receptor subunit of interleukin - 2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

Still, says Weiner, there are ways to enhance efficacy, for instance by trying more or different genes or by using a so - called prime - boost strategy, in which the DNA vaccine is followed by a shot with the protein subunits themselves.

To take that step, researchers from the Max Planck Institute for Molecular Cell Biology and Genetics and the University of Hamburg's Heinrich Pette Institute for Experimental Virology and Immunology began with the bacterial enzyme Cre recombinase, which exchanges any two pieces of DNA flanked on either end by a certain pattern of nucleotides (DNA subunits) known as loxP.

Researchers also knew that the composition of the receptor, which is made up of four subunits, is different in children than in adults, says Princeton University neurobiologist Joe Tsien; in children, who generally have better memories and seem to learn faster, the receptor contains more of the subunit called NR2B.

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis.

The drugs the scientists had been studying are antibiotics that attack a subunit of the malaria parasite called the apicoplast, which has some similarities with bacteria.

In this study, we identified three new broadly neutralizing VHH, which bind to the CD4 - binding site of the Env subunit gp120 and bind the molecular probe used to isolate VRC01.

Examples of adipose tissue transcripts whose expression correlated with body mass include (a) Csf1r and (b) CD68 antigen (Cd68), which correlated positively with body mass, (c) succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(Sdhb), and (d) ubiquinol — cytochrome c reductase subunit (Uqcr), which correlated negatively with body mass.

In 1967 Silvio S. Varon and Eric M. Shooter of the Stanford University School of Medicine isolated NGF by a different procedure and found that the NGF dimer was present as a stable complex with two copies each of two other proteins, which they designated the alpha and gamma subunits.

Focus of this project is the CaaX processing microcompartment transiently formed at the ER, which is required for the modification of yeast Chs4, a regulatory subunit of the chitin synthase (CHS) III complex.

The best - studied integrins, which are found in platelets and other tissues, have beta - 3 subunits.

In SIRT6 knockout mice, which exhibit accelerated aging phenotype, haploinsufficiency of p65 subunit of NF - kB resulted in improved lifespan 33.

Hargreaves brings her knowledge of biochemistry and epigenetic regulation to investigate a subunit of the SWI / SNF complex called ARID1A, which is mutated in many solid tumors, such as in ovarian, bladder and colorectal cancers.

The cytosolic catalytic domain consists of 3 A subunits and 3 B subunits, which bind and hydrolyze ATP, as well as regulatory accessory subunits.

And when they generated a strain of Drosophila which had only one working copy of dC53 (CG5147), a gene that encodes a Pol III subunit, these fruit flies lived longer too.

The culprit is one of the two subunits that make up the IKK protein complex, which is known to regulate several biological processes including inflammation.

The restoration of the ETS structure and function was confirmed by in - gel activity assay of complex I, which demonstrated an increase in activity to 30 — 40 % of that in WT cells in cybrids transfected by constructs containing all three modifications; it was also supported by the «marked» increase in levels of COX2 and ND6, both of which are mitochondrially - encoded ETS subunit component proteins.

Similar to these projects, IDRI's subunit tuberculosis vaccine, ID93, also utilizes adjuvants that induce a cell - mediated immune response, which is required for protection against M. tuberculosis infection in low dose aerosol models of TB.

Previous research has shown that prions are composed of two subunits — the prion - determining region and a functional domain which performs some function.

The B - subunit of the bacterial Shiga toxin (STxB), which is nontoxic and has low immunogenicity, can be used for tumor targeting of breast, colon, and pancreatic cancer.

His basic studies have allowed him to validate the B - subunit of Shiga toxin (STxB) as a «pilot» for the delivery of therapeutic compounds to precise intracellular locations of dendritic and tumor cells (10 patent families, 5 of which are delivered in the US, Europe and other countries).