Sentences with phrase «which systemic factors»

Not exact matches

These factors — many of which are beyond our control and the effects of which can be difficult to predict — include: credit, market, liquidity and funding, insurance, operational, regulatory compliance, strategic, reputation, legal and regulatory environment, competitive and systemic risks and other risks discussed in the risk sections of our 2017 Annual Report; including global uncertainty and volatility, elevated Canadian housing prices and household indebtedness, information technology and cyber risk, regulatory change, technological innovation and new entrants, global environmental policy and climate change, changes in consumer behavior, the end of quantitative easing, the business and economic conditions in the geographic regions in which we operate, the effects of changes in government fiscal, monetary and other policies, tax risk and transparency and environmental and social risk.

On the other hand, there are patients who do not show any significant improvement even after the second or third biologic drug treatment — typically with TNF inhibitors (which blockade the Tumour Necrosis Factor TNF, which is involved in systemic inflammation).

These factors have created a perfect storm, increasing free radical production and systemic inflammation, which leads to accelerated aging and chronic disease.

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

Mucuna has an added benefit in that it fights systemic redness in the brain, which is often a factor in brain degradation.

SIBO also causes systemic inflammation, which, as we know, is a major risk factor for cardiovascular disease.

Both factors may elicit a sympathetic and hypothalamic — pituitary — adrenal (HPA) axis response, which drive increased systemic reactive oxygen species production, chronic inflammation, and a metabolic substrate shift toward carbohydrate and away from fat oxidation, manifesting in an array of signs and symptoms often labeled as the overtraining syndrome.16

Public subsidizing of private schools, which have shown no educational efficacy when socioeconomic factors are accounted for, is contributing to the systemic destruction of public education.

When sentencing an Aboriginal offender, courts must consider: (1) The unique systemic or background factors which may have played a part in bringing the particular aboriginal offender before the courts.To do this courts are to take judicial notice of such matters as the history of colonialism, displacement, and residential schools and how that history continues to translate into lower educational attainment, lower incomes, higher unemployment, higher rates of substance abuse and suicide, and higher levels of incarceration for Aboriginal peoples.

First, the sentencing judge should consider «the unique systemic or background factors which may have played a part in bringing the particular aboriginal offender before the courts».

(A) The unique systemic or background factors which may have played a part in bringing the particular aboriginal offender before the courts; and

«The classification of all the information obtained will be subject to an all - round systemic analysis which will uncover the factors that affect a specific cryptoasset.

But the systemic factors — workplace culture, policies, power, funding and criteria on which decisions are made — are critical if we want a culturally equitable society.

Guided by the resilience factors from the systemic - constructivist theory, we identified which elements and links are empirically supported in pediatric oncology.