Anyone in the medical field, including doctors and pharmacists who are able to prescribe medications, are obligated to perform the adequate analysis as to
which type of drugs to give to the patients.
Not exact matches
There are actually a few
of those
drugs now: Cervarix, made by GSK,
which targets strains 16 and 18; Gardasil, made by Merck,
which preempts those two killers, plus strains 6 and 11; and Merck's Gardasil 9,
which primes the body's immune system to create protective antibodies against — you guessed it — nine
types of HPV.
Intarcia has completed several late - stage clinical trials in
which it uses the pump to deliver a glucose - controlling
drug continuously for months — an idea, that if successful (and approved by the FDA) could significantly help patients with
type 2 diabetes, fewer than half
of whom maintain the recommended glycemic levels.
What Boger wants is to create a better way to develop
drugs: through a process called structure - based design in
which scientists build up a new
drug, atom by atom, after determining the
type of molecule that might interrupt the disease process.
These
types of drugs could potentially be used with other sorts
of immunotherapies,
which are all the rage in biopharma these days.
So, Loncar took matters into his own hands and created a new
type of biotech index that focuses exclusively on the red - hot field
of cancer immunotherapy
drugs (treatments
which use the body's immune system as a conduit to fight cancer).
Its
drug Niraparib kills cancer cells by inhibiting the production
of proteins called PARPs,
which help repair damaged DNA strands, thereby hastening the death
of some
types of cancer cells.
Another study regarding one
of the diseases most affecting our modern society shows that «curcumin is 400 times more potent than Metformin, a diabetic
drug, in improving insulin sensitivity
which can help reverse
Type 2 Diabetes».
According to its spokesperson, Colonel Sani Kukasheka Usman, there was heavy exchange
of gunfire in
which the patrol killed 4 suspected Boko Haram terrorists, recovered 2 AK - 47 rifles, 4 various sizes
of solar energy panels, several
types of drugs and 5 motorcycles.
It classifies
drugs using a risk assessment matrix,
which covers nine
types of term divided between physical harm, dependence and social harms.
In some 3000 elderly people, Nir Barzilai
of the Albert Einstein School
of Medicine in the Bronx, New York, and his colleagues plan to conduct a trial in
which half the subjects would get a placebo and half would get an old (indeed, ancient)
drug for
type 2 diabetes called metformin,
which has been shown to modify aging in some animal studies.
They compared the concentrations
of proteins in the retinas
of non-diabetic mice,
of mice with
type 2 diabetes without treatment and
of type 2 diabetic mice that were treated with the standard
drug metformin,
which lowers blood glucose levels and thus reduces diabetes complications.
Students learn their application when analyzing samples for dyes, such as those occurring on textile fibers; when analyzing samples for the presence
of materials such as petrol
which may have been used to start fires; or when testing for the presence
of illicit
drugs in a variety
of sample
types.
The researchers designed a molecule combining 7,8 - dihydroxyflavone,
which mimics a protein critical for development and function
of the nervous system, and bisphosphonate, a
type of drug that sticks to bones.
He said: «This is an entirely novel
type of intervention
which could be added to community - wide campaigns with antimalarial
drugs, such as mass
drug administration and seasonal malaria chemoprevention, to kill both mosquitoes and parasites.
Also, another interesting
type of project is what are called Investigator's Brochures,
which are basically extensive reports detailing all the research on a prospective
drug to date.
In their paper,
which appears the journal Biomaterials, the researchers demonstrated that they could load the gels with two antimalarial
drugs, and they expect the material could also be used to carry other
types of drugs.
Qingdong Zheng, a materials scientist at John Hopkins University in Baltimore, Maryland, suggests that such biolasers could find uses in new
types of sensors or in light - based therapeutics, in
which light is used, for example, to kill cancer cells by triggering
drugs into action that have already been administered.
The task force also wants to expand a
type of trial that tests different
drugs in separate arms against the same control group,
which they say is more efficient than running a control group for each
drug.
Problematic video game use isn't all that different from other
types of addictive behavior, such as alcohol or
drug abuse,
which can be spurred by poor coping strategies.
Problematic video game use isn't all that different from other
types of addictive behavior, such as alcohol or
drug abuse,
which can be spurred by poor coping strategies, Hilgard said.
A single
type of bacteriophage can be adapted to a wide range
of bacteria, an innovation
which will likely accelerate the development
of potential
drugs based on this principle.
These two
drugs also bear the highest risk
of metabolic syndrome,
which encompasses weight gain and other related disorders, including
type 2 diabetes, according to a 2011 study
of 90 people with schizophrenia.
The report indicates that Sestrin 3 plays a critical role in regulating molecular pathways that control the production
of glucose and insulin sensitivity in the liver, making it a logical target for
drug development for
type 2 diabetes and metabolic syndrome,
which can produce increased blood pressure, abnormal cholesterol levels and insulin resistance.
«These include different
types of MRI scans,
which use strong magnetic fields and radio waves to produce detailed images
of the inside
of the brain, and Positron Emission Tomography (PET) scans,
which use a small amount
of a radioactive
drug, or tracer, to test how tissues in the brain are actually functioning.
Just a few weeks ago, WHO said that using any
of the experimental
drugs or vaccines in the pipeline simply wasn't in the cards, because none
of them have been through a phase I clinical study, the
type of trial in
which medical products are tested on healthy volunteers to study their toxicity.
Additional funding would support the exploration
of which types of memory are best treated by current
drugs or brain stimulation and how these can be improved.
Low doses
of aspirin, an anti-platelet
drug, have been shown to reduce the risk
of some
types of gastrointestinal cancers, but the process by
which aspirin hampers tumor growth has been unclear.
Their most powerful tool in this job is the randomized controlled trial, a
type of experiment in
which researchers separate participants into two or more groups and subject some
of them to the intervention to be studied, like a new
drug or surgical procedure.
But, this
type of study is not always used when testing new medical products for FDA approval, and it is particularly rare for new devices,
which are subject to different regulatory procedures from prescription
drugs.
The process consists in knowing the
type of proteins in charge
of metabolizing the
drugs (enzymes) for each patient
which would, helped by a mathematical model, allow to establish the exact dose needed
of the immunosuppressive
drugs required.
As neuroscience progresses, therapists continue to try to refine
which mixes
of drugs and behavioral therapy are best for
which types of ADHD.
On the other hand, L90M and K103N can also multiply in the absence
of drugs,
which means that untreated patients can propagate these two
types of resistance.
J. Marc Simard, professor
of neurosurgery at the University
of Maryland School
of Medicine, along with colleagues at Yale University and Massachusetts General Hospital, found that Cirara, an investigational
drug, powerfully reduced brain swelling and death in patients who had suffered a
type of large stroke called malignant infarction,
which normally carries a high mortality rate.
And the over-the-counter
drug cimetidine,
which inhibits acid production in the stomach and is used to treat heartburn, matched a certain
type of lung cancer.
«A better understanding
of the brain region and cell
type - specific binding targets
of Hnrnph1 will tell us more about the function
of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for
which there is currently no FDA - approved
drug,» explained corresponding author Camron Bryant, PhD, assistant professor
of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.
«Current trends in the neuroscience field, particularly in alcohol research, indicate that
drugs which are used to treat various
types of cancer, such as HDAC inhibitors, appear to be very important in regulating brain function,» said Subhash C. Pandey, Ph.D., professor and director
of the Alcohol Research Center at the University
of Illinois at Chicago.
A research group at the University
of Tokyo has demonstrated the mechanism by
which an enzyme used in industrial production
of an important
drug for
type - 2 diabetes recognizes its target.
His contributions to microbicides for HIV prevention spans two decades and culminated in the CAPRISA 004 tenofovir gel trial
which provided proof -
of - concept that antiretroviral
drugs can prevent sexually transmitted HIV infection and herpes simplex virus
type 2 in women.
Mike Kuhar, a neuroscientist at Yerkes National Primate Research Center, introduced the topic
of cognitive enhancers or â $ œsmart
drugs.â $ He described one particular class
of proposed cognitive enhancers, called ampakines,
which appear to improve functioning on certain tasks without stimulating signals throughout the brain. Kuhar questioned whether â $ œsmart drugsâ $ pose unique challenges, compared to other
types of drugs.
He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for
drug screening and tissue therapy, but they would also provide a benchmark against
which other
types of stem cells could be measured in terms
of their effectiveness in stem cell therapy and regenerative medicine.»
Breast and ovarian tumours lacking one
of these two genes are more sensitive to a new - generation chemotherapy, the PARP inhibitors,
which is revolutionising
drug treatments in this
type of cancer.
The structure
of these transporters is essential to the rational design
of agents
which control their function.30 - 32 In our current work we investigated the chemotherapy agent cisplatin since it the most used chemotherapy
drug for a number
of cancer
types and the application would have an impact on several cancers.
Our therapeutic siRNA molecules are combined with delivery systems,
which markedly enhance the efficiency and specificity
of our siRNA
drugs by directing them to the right cell
type in the body and sparing healthy tissues.
A Korean research team from KAIST developed a computational framework, DeepDDI, that accurately predicts and generates 86
types of drug -
drug and
drug - food interactions as outputs
of human - readable sentences,
which allows in - depth understanding
of the
drug -
drug and
drug - food interactions.
Very importantly, DDI
types predicted by DeepDDI are generated in the form
of human - readable sentences as outputs,
which describe changes in pharmacological effects and / or the risk
of ADEs as a result
of the interaction between two
drugs in pair.
DeepDDI was first used to predict DDI
types of 2,329,561
drug pairs from all possible combinations
of 2,159 approved
drugs, from
which DDI
types of 487,632
drug pairs were newly predicted.
The
drug, exendin - 4 (marketed as Exenatide),
which mimics the effects
of GLP - 1, is used to lower blood glucose in
type 2 diabetes.
1987 — We discover a molecule that would later become the important
drug temozolomide (Temodal),
which is used worldwide today to treat people with the most common
type of brain tumour, glioblastoma.
The result was a highly selective
drug they named SBI - 0206965,
which successfully killed a number
of cancer cell
types, including human and mouse lung cancer cells and human brain cancer cells, some
of which were previously shown to be particularly reliant on cellular recycling.