Sentences with phrase «while expression levels»

Following purification, recombinant proteins were quantitated by ELISA and while expression levels varied significantly between individual proteins, most were purified to micromolar levels (Table 1).

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

Not exact matches

His reciprocal analysis retains the importance of a rational expression of the real (as the primary means whereby we express an explicit understanding of the world as such, both to ourselves and to others) while at the same time recognizing the aesthetic dimension that is present in any level of understanding (as grounded in the immediacy of experience).

But edit the RNA and the genetic machinery stays the same while the proteins can be manipulated, so the levels of gene expression are dialed up or down.

RNA polymerase in bacteria controls the expression of all genes, but in response to the presence of ppGpp, the expression levels of some genes are turned down, while many are unaffected and some are turned up.

Three decades of research have shown that loneliness can affect levels of stress hormones, immune function, and even gene expression, while human interaction increases levels of oxytocin, a bonding hormone that reduces blood pressure and cortisol levels.

The importance of CCR5 for HIV - 1 pathogenesis is shown by the fact that individuals who are homozygous for an inactivating 32 base pair deletion in ccr5 (ccr5Δ32) are highly resistant to HIV infection [2], [3], while heterozygotes typically live longer after HIV infection due to reduced CCR5 expression levels [4], [5].

Overexpression of wild - type ACVR1 in chick micromass cultures resulted in expression levels of marker genes that are comparable to those of the empty viral vector, while cells overexpressing R206H ACVR1 showed upregulation of collagen type II and aggrecan.

While the European honeybee kakusei showed a expression peak 15 min after seizure induction [13], the expression level of the Acks transcript reached a maximum 30 min after seizure induction (Figure 1B).

While S. pistillata's galaxin - like gene was up - regulated during the daytime treatment, the galaxin gene was down - regulated, and was similar to night - time expression levels.

CR increases the expression levels of SIRT1 7, 8, SIRT3 9 and SIRT5 10, while high fat diet has been demonstrate to reduce SIRT1 expression 11.

While in treatment with addition of 100 mg / L calcium, relative expression of galaxin was dropped to expression level similar to expression during night - time (relative expression of 17.72 ± 2.61 at 23:00, C23 in Fig. 5A).

Supplementary Fig. 36a shows the performance of the model based on the TIN measure at the tissue level, while Supplementary Fig. 36b compares the predictions based on TIN with the predictions based on gene expression at the individual level.

In the AD mice, the expression of ERK1 / 2 was significantly increased (p < 0.05), while the level of BDNF was decreased (p < 0.05).

Inhibition of FGF signalling with PD173074 (10 nM) increases the levels of Nanog gene expression in two HV clones while slightly reducing low - level Gata6 expression.

RT - PCR analysis of RNA from mouse embryonic and adult gonads using primers corresponding to either exons 3 and 9 (upper panel, 501 - bp band) or exons 3 and 12 (lower panel, 847 - bp and 712 - bp bands) reveals that full - length Bol1 is only expressed in postnatal testes, while Bol2 lacking exon 11 is also detectable at low levels throughout gonadal development in addition to its high adult testis expression.

In rostral brain regions, high expression levels in the dorsal lateral striatum, while in the caudal brain regions, high levels are observed in the ventral lateral striatum (PubMed: 10891614).

While the role that DNA - binding proteins play in regulating gene expression at the transcriptional level is well studied, how RNA - binding proteins control gene expression at the post-transcriptional level is less clear.

Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumor suppressor FoXO3 gene in cells.

Interestingly, while high levels of fluorescence and the expression of Hex and Cerberus mRNA required activin, low levels of Venus fluorescence were detected in the absence of activin.

While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression levels of both targets and transporters have also been reported.

With filmmakers such as Coogler and Johnson — alongside Jenkins, Waititi and other creators of handcrafted blockbusters — blazing a trail, hopefully more filmmakers will find a way to satisfy the needs of the system while also building vehicles for personal expression and achievement of craft at the highest levels.

The entry level Expression starts at # 9495, and while that's more than a VW Up or Toyota Aygo, the Twingo comes with a relatively healthy equipment list, including power steering, electric windows, remote central locking, ESP and a tyre pressure monitoring system.

«How could we best encompass such strong Chrysler models as the Crossfire, which began the brand's move toward a higher level of performance and elegance, while looking to the most extreme expression of engineering and design such as last year's prototype, the ME Four - Twelve?

As is the case with the rest of the Renault range, the trim levels have been broken down into Authentique, Expression, Dynamique, Initiale and GT versions, while the Carminat and Privilà ¨ ge Carminat versions take on flagship status.

With clarity of expression, Maathai analyzes the most egregious «bottlenecks to development in Africa» occurring at the international, national, and individual levels — cultural upheaval and enduring poverty, among them — and deftly describes what Africans can and need to do for themselves, stressing all the while responsibility and accountability.

Another interesting difference is that in the Japanese versions, Ristar had two different expressions while standing / idling — a happier one during the normal levels and a more serious one during the boss stages.

The most us mere mortals can usually hope for is tackling a level with some small grace, which makes efforts such as this video, of someone perfecting Ikaruga (Radiant Silvergun's spiritual successor) while controlling both ships himself, the ultimate expression of danmaku.

While Twigs felt it was liberating as an artist, Israel said that digital technology has given the general population a set of tools that allows for new levels of creative expression.

While some paintings in the show are interspersed with figurative elements, Chris Martin is fully committed to an abstract style of painting that enables him to access different levels of language and image in limitless expression.

McGrath J, by contrast, while recognising the importance of freedom of expression, said that the earlier Court of Appeal decision in Melser had incorporated «freedom of expression as a balancing factor in deciding if conduct reaches the level of being disorderly».

While its tubby little frame may look innocuous enough, the system's 8 - man assault team of drivers provides thick and full bass response, precise detail in the midrange and treble, and an impressive level of dynamic expression, all cast from a cylindrical cabinet to create an enjoyable audio experience from any angle.

Several investigations found that conduct problems coupled with low levels of CU traits are associated with increased amygdala reactivity to fearful and angry facial expressions (Viding et al., 2012; Hyde et al., 2013; Blair et al., 2014; Sebastian et al., 2014), while those coupled with high levels of CU traits are correlated with decreased amygdala reactivity to emotional stimuli, particularly fearful facial expressions (Odgers et al., 2008; Jones et al., 2009).

In accordance with the positive and negative affect models, we expect that expression of criticism will be associated with short term dissolutions, while low levels of emotional support will predict long term dissolutions.

The first parameter is Mean TL - BS and is a bi-dimensional parameter, calculated twofold for each of the congruent and incongruent set of trials, in the case of each participant; Mean TL - BS positive (Mean TL - BS Toward) indicates individual differences in the degree to which the attention is oriented toward the emotional face or to which the mean TL - BS > 0 ms, whereas Mean TL - BS negative (Mean TL - BS Away) reflects individual differences in the degree to which the attention is oriented away from the emotional face or the degree to which TL - BS < 0 ms.. The second parameter is Peak TL - BS, which is also bi-dimensional and calculated twofold; Peak TL - BS positive (Peak Toward) shows the individual differences in the maximum phasic expression of the trial - level orientation toward the emotional face, while Peak TL - BS negative (Peak Away) indicates the individual differences in the maximum phasic expression of the trial - level attention away from the emotional face.