Sentences with phrase «whire cell infiltration»

In this study, immune cell infiltration of the lungs increased, and Th2 responses became more prominent.

«In this study we found that NF - κB activity is strongly associated with immune system T - cell infiltration in lung cancer,» explained study co-author Dung - Tsa Chen, Ph.D., member of the Biostatistics Department at Moffitt.

The investigators also found that there was a decrease in blood vessels and lymphocytic cell infiltration, both in AA98 - treated and V1q - treated mice, whereas a more significant decrease was observed in the combination treatment group.

In addition, the researchers reported that MMP - 3 induced blood cell infiltration and hemorrhage after SCI in wild - type mice, but not in Mmp3 knockout mice.

IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease

Blame for treatment failures is usually attributed to so - called «cold» tumors, those that do not attract T - cell infiltration and may lack key T - cell targets — the mutated proteins known as neoantigens.

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.

«This is the first identified cell - intrinsic cancer - causing pathway that disrupts T cell infiltration in melanoma,» said study author Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

Increased T - cell Infiltration Elicited by Erk5 Deletion in a Pten - Deficient Mouse Model of Prostate Carcinogenesis.

Here we present a novel human Airway Lung - Chip containing a fully - differentiated human mucociliary airway epithelium separated from a pulmonary microvascular endothelium by a semi-permeable membrane that allows for immune cell infiltration.

Mock - infected control (A); Severe hemorrhage and regression of ovarian follicles (B); Spleens from mock - infected control (left) and enlarged spleens from the infected ducks (C); HE - stained ovary section showing hemorrhage and follicle rupture with red stained bodies (D); HE - stained brain section revealing lymphocytes and mononuclear cell infiltration under cranial arachnoid (E) and focal gliosis (arrow)(F).

The study also demonstrated that at the highest dose, DG031 lowered levels of sICAM - I, a critical molecule in the activation of inflammatory cells and cell infiltration.

These grafts showed preservation of the muscle architecture and lack of mononuclear cell infiltration in the syngeneic and tolerant grafts, but massive tissue destruction in the acutely rejected control grafts.

Astaxanthin has been shown, when take in concordance with other carotenoids, to protect against free radical induced DNA damage, repair UVA - Irradiated cells, and inhibit inflammatory cell infiltration.

And that can drive a lot of B cell infiltration.

Nevertheless, certain histologic features of chronic bronchial disease are characteristic and include goblet cell hypertrophy and hyperplasia, mononuclear cell infiltration, and increased connective tissue within the lamina propria.

Inflammatory cell infiltration of pancreatic islets occurs in 46 % of diabetic dogs (83), and ∼ 50 % of diabetic dogs have circulating antibodies against β - cells (70 — 72).

Histopathologic examination of muscle biopsies revealed multifocal areas of mixed mononuclear cell infiltration, myonecrosis and regeneration.

These may be injuries over the cornea, infections in ophthalmic tissues, inflammatory cell infiltration into a transparent eye medium and degeneration of the cornea or the lens of the eye.

Not exact matches

Further investigations showed that the mutation causes reduced CTLA - 4 function, which led to increased infiltration of the intestinal mucosa by T - cells and therefore to chronic diarrhea.

Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells.

«Injecting the human blood cells resulted in massive liver cell damage and we were able to detect cytotoxic T lymphocytes that specifically targeted hepatitis B virus in liver infiltration cells.

The researchers reported the natural inflammatory response when a foreign substance like a hydrogel is introduced into a system and draws cells that secrete proteins involved in cellular infiltration, scaffold degradation, vascularization and innervation.

Once Hartgerink and his team started to investigate the phenomenon, they found that even without additives their MDP is rapidly infiltrated by host cells, provokes a temporary inflammatory response, does not develop a fibrous capsule, supports the infiltration of a mature vascular network and recruits nerve fibers.

That reaction results when a localized accumulation of immune complexes — antibodies bound to their antigens — is deposited in tissue and sets off an inflammatory response involving the infiltration and activation of immune cells, initially the neutrophil.

Using tumor biopsies from melanoma patients, the researchers could show that there is a positive correlation between the production of CCL5 and the infiltration of NK cells.

Heart tissue from that individual revealed infiltration of white blood cells called eosinophils.

In their newly published study, the researchers aimed to investigate the effect of blocking autophagy on the infiltration of NK cells in melanoma.

When CCL5 is depleted, the infiltration of NK cells and the subsequent regression of tumor volume were no longer observed, thus confirming the crucial role of CCL5 in driving NK cells into autophagy - defective tumors.

However, tumor cells can circumvent this immune defense by establishing a surrounding microenvironment that prevents the infiltration of NK cells and thus promotes tumor survival and growth.

In addition, older tissues tend to exhibit more chronic inflammation — a low - level infiltration of immune cells and substances.

Professor Aoki says, «By controlling the intercellular transmission of ERK activity in the future, it may be possible to suppress the infiltration of cancer cells.»

To explain their findings, the authors suggest that resveratrol's vasodilating effects via endothelial cells might enhance infiltration of inflammatory cells into the central nervous system, which in turn might play a key role in the pathogenesis of MS.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Schneck says some scientists have emphasized that response to immunotherapy is largely dependent on whether T - cells are infiltrating the tumor site, but his research suggests that while, «infiltration is important, it's not enough to explain patients» variable responses to immunotherapy drugs.»

Cortisone helps to enhance the barrier function of the endothelium, preventing vascular leakage and further infiltration of the alveolar space by immune cells.

One third of these mice developed severe hepatic steatosis (infiltration of liver cells with fat), neutrophil infiltration, and necrosis, similar to that seen in patients with alcoholic hepatitis.

Despite the increased production of proinflammatory molecules, infiltration of adipose tissue by inflammatory cells has not been described as a common feature of obesity.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

Histopathology in Tg197 mice is characterized by infiltration of inflammatory cells, synovial hyperplasia, articular cartilage destruction and bone erosion symptoms, closely resembling those of human rheumatoid arthritis.

Background: Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

ADCC / ADCP - enabling isotypes of a-TIGIT surrogate Ab show potent monotherapy efficacy in murine tumor models that correlates to increased T cell activation and reduced Treg infiltration of tumors.

In ligase deficient mice, growth of mouse melanoma cells in vivo is attenuated, while tumor infiltration by CD4 + / CD8 + T cells and dendritic cells is increased.

The brain is generally considered an immune - privileged environment and immune cell leukocyte infiltration is known to be tightly regulated [21], [22].

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

Scoring - 0 - no definite pathology, 1 - mild peribronchiole and perivascular cellular infiltration, 2 - moderate peribronchiole and perivascular cellular infiltration, 3 - severe peribronchiolar and perivascular cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell necrosis and debris in the lumen.

Figure 2: Representative histology images of A: wild type and B: Tg197 animals at 7 weeks of age depicting the symptoms of Infiltration of inflammatory cells, Synovial hyperplasia, Articular cartilage destruction and Bone erosions evident as Tg5453 arthritic pathology.

In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).