A more recent study found that cold applied to human neck fat initiated the conversion [21] of
white fat cells into brown ones.
Furthermore, he demonstrated that a class of drugs often used in the treatment of diabetes also reduces the harmful effects
of white fat cells on bones.
As toxins are known to deposit
in white fat cells, this action greatly boosts toxin elimination.
Other research groups are also generating promising results through the use of drugs to
convert white fat cells into brown fat and through discoveries of the pathways and hormones that control brown fat metabolism.
In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity -
linked white fat cells.
But
since white fat cells have very few nerves, how do beige fat cells get the message that it's cold outside?
More beige fat cells and
fewer white fat cells could reduce the symptoms or negative health outcomes of metabolic diseases like diabetes, obesity.
Another cell, called a beige fat cell, is an energy - burning cell that comes from the same precursor cell
as white fat cells.
Since toxins are known to live
in white fat cells, this action is believed to effectively boost toxin elimination.
Now researchers from the University of Southern Denmark have uncovered the mechanism by which
white fat cells from humans get reprogrammed to become browner.
The challenge is to reprogram the energy
storing white fat cells into so - called «brite» (brown - in - white) fat cells in the body's white adipose tissue and thus make adipose tissue burn off excess energy as heat instead of storing it.
In the laboratory, irisin and FGF21 turn
human white fat cells into brown fat cells over a period of six days.
In analyses of the cell lines,
precursor white fat cells from two subjects responded strongly to BMP7 but such cells from the other two subjects did not.
Those epigenetic changes
transform white fat cells into what researchers refer to as «beige fat cells,» which perform thermogenesis like brown fat cells.
«The data here show
how white fat cells can make maximal use of their limited number of nerves to allow a single nerve fiber to spread the «message» about cold temperatures amongst the connected cells,» explained Dr. Philipp Scherer, lead author of the study and Director of UT Southwestern's Touchstone Center for Diabetes Research.
Schulz further demonstrated that a drug class widely used to treat diabetes inhibits an enzyme that is produced
by white fat cells in the bones.
Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into
white fat cells instead.
«The discovery of the «brite» fat cell mechanisms and the specific regulatory areas brings us closer to understanding how reprogramming of
white fat cells takes place.
When researchers inhibited the activity of this molecule genetically or pharmacologically,
white fat cells lit up their cellular furnaces, becoming calorie burners like their brown and beige brethren.
The bile acids accumulate in the blood and interact with the TGR5 receptor
on white fat cells to change their metabolic function.
Scientists at the University of Bonn have shown in mice that excess pounds can simply be melted away by converting
unwanted white fat cells into energy - consuming brown slimming cells.
«To date, there are no drugs which directly
cause white fat cells to convert into brown fat cells,» says Prof. Pfeifer.
Prof. Dr. Alexander Pfeifer from the Institute of Pharmacology and Toxicology at the University of Bonn has spent years researching how
harmful white fat cells can be converted into desirable brown fat cells.
For a long time, scientists have dreamt of converting
undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away.
«The inflammation factor TNFalpha suppresses the cGMP signal path and thus
prevents white fat cells from being turned into brown fat cells.»
Mice that received normal levels of prenatal vitamin A, from a regular diet, were born with more fat -
loading white fat cells, fewer brown fat cells and fewer blood vessels.
Unlike
ubiquitous white fat cells, which lounge around storing fat, rarer brown ones burn fat at a higher rate as part of a duty to keep us warm.
Previous research found that exercise prompts muscles to secrete this protein fragment into the bloodstream, and that it may help burn fat by causing energy -
storing white fat cells to act like energy - burning brown fat cells, although its activity in humans is still controversial.
Such analyses will improve our understanding of how brown fat cells develop and are regulated in the body — and, potentially, how to transform the precursors
of white fat cells into brown fat cells instead, says Dr. Tseng.
In one example, Dr. Tseng's group previously had shown that exposing
precursor white fat cells to a protein known as BMP7 helps to spur the creation of brown fat cells.
«In studies in mice, we have found various starting points to convert
troublesome white fat cells into desirable brown fat cells,» reports Prof. Pfeifer.
Although
transforming white fat cells into beige fat cells and increasing thermogenesis is naturally a stress response to chronic cold exposure involving adrenaline, researchers report that the same white - to - beige fat cell transition can be caused without adrenaline or cold stress.
The group is planning future studies that look at the effect of activating ERRγ
in white fat cells — which they suspect could make some white fat resemble brown fat, and potentially help treat obesity and diabetes.
These hormones fired up the energy - burning rate of
human white fat cells in the laboratory, and the treated fat cells began to emit heat — a hallmark of brown fat function.»
The mice then had significantly more brown fat cells available than did the control gro up — and had even
converted white fat cells into brown fat cells.
The study shows that activating the bile acid receptor TGR5 with molecules that mimic the action of bile acids (so called «mimetics») induces a remodeling of
white fat cells into beige fat cells.
Some white fat cells are capable of transforming into a third kind of fat, beige.
His work uncovered a way that fat and muscle communicate with each other through specific hormones — turning
white fat cells into brown fat cells to protect us against cold.
Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and
white fat cells, as well as on cells of the urinary bladder and other tissues.
The team found that brown fat cells express the ERRγ gene all the time (not just in response to cold) and
that white fat cells do not express the gene at all.
Because calorie restriction induces fat breakdown in
white fat cells, they probed possible links between lipid processing and SIRT1.
There are three different types of fat cells:
white fat cells, which store energy; brown fat cells, which expend energy; and the so - called «beige» fat cells, which are functionally related to brown cells while being located in typically white - fat depots.
In the new study, published in Cell Reports, scientists in the laboratory of Gladstone Senior Investigator Sheng Ding, PhD, used cellular reprogramming to convert muscle precursor cells and
white fat cells into brown fat cells.