A more recent study found that cold applied to human neck fat initiated the conversion [21] of
white fat cells into brown ones.
The team says that this is a result of the oil triggering receptors in the digestive tract, activating the sympathetic nervous system and converting
white fat cells into the beige variety.
UCSF researchers have discovered how to convert
white fat cells into calorie - burning brown fat cells
In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of
white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 protein.
Although transforming
white fat cells into beige fat cells and increasing thermogenesis is naturally a stress response to chronic cold exposure involving adrenaline, researchers report that the same white - to - beige fat cell transition can be caused without adrenaline or cold stress.
The mice then had significantly more brown fat cells available than did the control gro up — and had even converted
white fat cells into brown fat cells.
Scientists at the University of Bonn have shown in mice that excess pounds can simply be melted away by converting unwanted
white fat cells into energy - consuming brown slimming cells.
The study shows that activating the bile acid receptor TGR5 with molecules that mimic the action of bile acids (so called «mimetics») induces a remodeling of
white fat cells into beige fat cells.
The challenge is to reprogram the energy storing
white fat cells into so - called «brite» (brown - in - white) fat cells in the body's white adipose tissue and thus make adipose tissue burn off excess energy as heat instead of storing it.
His work uncovered a way that fat and muscle communicate with each other through specific hormones — turning
white fat cells into brown fat cells to protect us against cold.
Other research groups are also generating promising results through the use of drugs to convert
white fat cells into brown fat and through discoveries of the pathways and hormones that control brown fat metabolism.
In the laboratory, irisin and FGF21 turn human
white fat cells into brown fat cells over a period of six days.
Not exact matches
Some
white fat cells are capable of transforming
into a third kind of
fat, beige.
Previous studies have found that brown
fat can be coaxed
into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and
white fat cells, as well as on
cells of the urinary bladder and other tissues.
Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused
fat cells that would normally become healthier beige to turn
into white fat cells instead.
The findings, published today in the journal
Cell, give new insights
into how the brain regulates body
fat and may lead to more effective ways to lose weight and prevent obesity by promoting the conversion of
white fat to brown
fat.
Activating RXR triggered a cascade of changes in muscle precursor
cells and
white fat that ultimately converted them
into brown
fat - like
cells.
If the Gq protein is blocked, undesired
white fat cells change
into energy - consuming brown
cells.
«To date, there are no drugs which directly cause
white fat cells to convert
into brown
fat cells,» says Prof. Pfeifer.
Prof. Dr. Alexander Pfeifer from the Institute of Pharmacology and Toxicology at the University of Bonn has spent years researching how harmful
white fat cells can be converted
into desirable brown
fat cells.
The brown
cells possess an extremely high number of mitochondria — these
cell power stations «burn»
white fat by converting it
into thermal energy.
«The inflammation factor TNFalpha suppresses the cGMP signal path and thus prevents
white fat cells from being turned
into brown
fat cells.»
«If we can design drugs that specifically stabilize PRDM16 protein, this can convert
white blood
cells into brown
fat with fewer side - effects.
As we get older, brown
fat cells change
into white fat cells.
It turns out that cold exposure has the potential [19] to transform
white adipose tissue
cells into metabolism - stimulating brown
fat cells.
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