Sentences with phrase «white matter disease»

An MRI revealed no sign of angiopathy in the carotid and vertebral arteries but did reveal evidence of deep white matter disease, demyelination and possible multiple sclerosis.

White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure

Educational level, mood symptoms and the severity of white matter disease were associated with risk for delayed post-ICH dementia after six months.

Not exact matches

Published in the Neurobiology of Aging, the study, which focused on detecting changes in the white matter connections of the brain, offers tantalizing potential for the identification of biomarkers connected to the development of dementia, including Alzheimer's disease.

If the approach also works with human cells, it could eventually lead to cell therapies for diseases like inherited leukodystrophies — disorders of the brain's white matter — and multiple sclerosis, as well as spinal cord injuries.

White matter hyperintensities, which appear as bright spots on brain MR images, are associated with accelerated motor and cognitive decline, Alzheimer's disease, stroke and death.

«Our results demonstrate that aortic arch pulse wave velocity is a highly significant independent predictor of subsequent white matter hyperintensity volume and provides a distinct contribution — along with systolic blood pressure, hypertension treatment, congestive heart failure and age — in predicting risk for cerebrovascular disease,» Dr. King said.

The study published in the Journal of Alzheimer's Disease focused on a type of brain tissue called white matter, which is composed of millions of bundles of nerve fibers used by neurons to communicate across the brain.

BACKGROUND AND PURPOSE White - matter hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small - vessel disease and neurodegenerative changes.

Spatial distribution of white - matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging.

The researchers found a link between abnormalities in white matter and a decrease in functional connectivity in the brain's default - mode network, a set of regions that typically shows abnormal behavior in people at genetic risk for Alzheimer's disease.

He also showed that DBSI could be used to examine the development of white matter inflammation in patients with neurodegenerative diseases and in animal models of these diseases.

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

Here the authors try combining probing white matter integrity with a MRI measure of whether the brain has shrunk as a result of disease.

AST - OPC1, an oligodendrocyte progenitor cell population derived from human embryonic stem cells, has been shown in preclinical testing in animals and in vitro to have three potentially reparative functions that address the complex pathologies observed in demyelination disorders, such as spinal cord injuries, and multiple neurodegenerative diseases, including multiple sclerosis and white matter stroke.

A failure of normal astrocyte generation by CNS precursor cells has been discovered to be a consequence of the mutations that cause Vanishing White Matter leukodystrophy [7], and dysfunction of astrocytes has also been suggested to be of importance in models of amyotrophic lateral sclerosis [8], forebrain ischemic injury [9], epileptic seizures [10], Huntington's disease [11], tuberous sclerosis [12] and Rett syndrome [13].

Extensive damage to white matter (myelin - rich brain areas) characterizes Alzheimer's disease, Huntington's disease, and Parkinson's disease, pointing to myelin damage and oligodendrocyte impairment as a common path to the progression of these diseases, even though each of these diseases may have a different cause.

Although multiple sclerosis (MS) is generally considered a disease of the white matter, recent evidence suggests substantial involvement of gray matter in cognitive decline and disease progression.

The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.

Progressive multifocal leukoencephalopathy (PML) is a rare disease of the brain's white matter caused by the John Cunningham polyomavirus (JCV), a usually harmless virus that infects up to 80 percent of healthy adults.

The white matter pathways comprise a set of active wires and the responses and properties of these wires predict human cognitive and emotional abilities in health and disease.

Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.

However, a more thorough analysis of the data revealed that the risk was being driven by women with signs of cerebrovascular disease — either a previous stroke or signs of white matter damage in their brains.

«White matter lesions seem to a play a role in Alzheimer's disease,» researchers explained.

One is Globoid Cell Leukodystrophy (Krabbe's disease), a brain disorder where the white matter of the brain breaks down.

Degenerative Myelopathy is a devastating disease that slowly takes away the white matter of the spinal cord.

The disease affects the White Matter tissue of the spinal cord and is considered the canine equivalent to amyotrophic lateral sclerosis (Lou Gehrig's disease) found in humans.

Progressive Multifocal Leukoencephalopath This is a white matter of the brain disease caused by a virus infection.