Sentences with phrase «whole genome sequences of»

We analyzed whole genome sequences of 1,680 Streptococcus pneumoniae isolates from four independent populations using GWAS and identified probable hotspots of genetic variation which correlate with phenotypes of resistance to essential classes of antibiotics.

Today the whole genome sequences of Woolly Mammoths are providing insight into adaptations for cold climates.

Now, with the whole genome sequences of four black - footed ferrets, two that were saved as living cells in San Diego Zoo's Frozen Zoo ®, and two living black - footed ferrets from the Black - footed Ferret Conservation Center in Colorado, we have information that can transform our understanding of aspects of black - footed biology.

Almost 10 years to the day after the human genome sequence was completed, a group of researchers has unveiled the first whole genome sequences of prostate tumors.

Called the stairway plot, it models the frequency of single nucleotide polymorphisms (SNPs) in whole genome sequences of hundreds of individuals.

Whole genome sequencing of modern and ancient horses unveils the genes that have been selected by humans in the process of domestication through the latest 5,500 years, but also reveals the cost of this domestication.

Plus, Chris Tyler - Smith discusses what whole genome sequencing of endangered mountain gorillas reveals about their genetic diversity and evolutionary history.

In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012).

In a new study scientists at SciLifeLab / Uppsala University and their colleagues report that whole genome sequencing of Atlantic and Baltic herring revealed hundreds of loci underlying adaptation to the brackish Baltic Sea or timing of reproduction.

But to do this, researchers need to overcome several non-trivial challenges inherit in assembling the whole genome sequence of parasites and the vectors that transmit them.

By comparing the whole genome sequence of the lab - cultured resistant strain with a sibling strain that had not been exposed to the drug, they were able to identify several mutations of interest in a number of genes.

Sanger Institute scientists performed whole genome sequencing of typhoid samples from Pakistan to investigate the genetic cause behind its high level of antibiotic resistance.

The first draft of the whole genome sequence of the coral Acropora millepora, the result of collaboration between the ARC Centre of Excellence for Coral Reef Studies (CoE) and the...

Whole genome sequencing of melanoma, the deadliest form of skin cancer, has confirmed the long - held belief that greater sun exposure...

Whole genome sequencing of more than 3,000 long - term St. Jude childhood cancer survivors found that 12 percent carried mutations in one of 156 genes that are associated with an increased risk of cancer for survivors or their children.

«We are very pleased to be able to offer human whole genome sequencing of up to 15,000 individual genomes per year, enabling scientists to perform internationally competitive studies of human diseases and evolution» says Ann - Christine Syvänen at NGI in Uppsala.

For whole genome sequencing of individual samples, we've used Maq with some success to map, assemble, and call variants from Illumina / Solexa reads.

This is a big leap forward with respect to the current gold standard of using one reference, 3D7 v3, which is the whole genome sequence of a single parasite.

«This study underscores the importance of whole genome sequencing of well - phenotyped populations.

The MHco3.N1 inbred line has subsequently been used to provide DNA template for whole genome sequencing of H. contortus.

Same - day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

Not exact matches

In the absence of a lucrative market, the X Prize's contest will give companies doing whole - genome sequencing a boost.

This time Venter turned to Diamandis (Page had introduced them) not because of a failure at the NIH but because financiers weren't supporting companies that did whole - genome sequencing.

With all due respect, if you'd read the actual study, you would see that this was not a whole genome sequence comparison; rather it was a comparison of mitochondrial 12S rDNA and 16S rDNA sequences for the purposes of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).

Meanwhile, technology limits the impact of the Supreme Court ruling: The falling price of whole - genome sequencing, which sidesteps patents altogether because it doesn't require isolating a gene, makes it a reasonable alternative to a patented BRCA - style test.

The country is offering whole genome sequencing to every citizen who wants it — a project that will chart the way for the future of genomic medicine.

So even though some of the leaders of the 2014 avian tree effort launched B10K, a project aiming to eventually sequence the whole genomes of all 10,560 bird species and from there build «the grand tree,» some bird researchers decided not to wait.

In new research, published in the journal FEBS Letters, scientists at the Quadram Institute carried out a search of the National Centre for Biotechnology Information's Whole Genome Sequence database.

He argues that whole genomes will not only provide more data for building trees, but will also enable researchers to study the evolution of regulatory sequences, transposable elements, and other aspects of the genome that are not covered with OpenWings sequencing.

In 2014, biologists published an avian tree based on the sequences of whole genomes of about 40 species.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

«That's why the power of whole - genome sequencing blows us away.

«We hope our findings will encourage others to use whole - genome sequencing as a method to determine all the off - target effects of their CRISPR techniques and study different versions for the safest, most accurate editing,» Dr. Tsang says.

Moreover, data collected from whole - genome sequencing showed that Ata's molecular composition aligned with that of a human genome.

However, the results of more recent phylogenetic analyses, derived from comparisons between sequences of specific genes and of whole genomes, seemed to point to Ctenophora as the first group that parted company with the lineage from which the rest of the animal kingdom (including sponges) evolved.

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

The new method by Garaycochea and colleagues will enable researchers to strategically analyze this whole - genome sequence data and assemble the chloroplast genome for their plant of interest.

We carried out detailed genetic studies and used whole genome sequencing to look at every part of the DNA at diagnosis, and every part of the DNA at relapse,» says Dr. Dick.

Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

They sequenced the first whole animal, the flatworm, in 1998, and then pushed the systems to handle big chunks of bigger genomes — billions of base pairs.

Gire et al. describe Ebola epidemiology on the basis of 99 whole - genome sequences, including samples from 78 affected individuals.

Whole - genome sequencing was used to study the differences in some of the major ethnolinguistic groups in the country.

Two study aims were to use novel whole - genome sequence data to (1) study possible correlations between language groups and genetic clustering, and (2) investigate the ancestral compositions of these individuals, including maternal and paternal lineages.

«Studies like the current one involving rhabdomyosarcoma are giving us a close - up look at the way cancer evolves in response to treatment,» said study co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequeGenome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequegenome sequencing.

This makes a lot of sense but it's been hard to prove without whole - genome sequencing.»

In the paper, the scientists show that combining the drug - resistance profile of a bacteria with its whole - genome DNA sequence allowed them to build up a series of drug - resistance «DNA photofits» for resistance to specific drugs.

Professor Ed Feil, joint lead author from the Milner Centre for Evolution, at the University of Bath, said: «We've developed user - friendly analysis software that demonstrates how whole genome sequence data can be a powerful tool for pan-European surveillance of MRSA and other important pathogens.

While the first whole genome sequence was completed in 2001 at a cost of $ 500 million, by 2014, we may finally see the $ 999 genome.

Using whole genome sequencing technology, researchers from The Netherlands have now succeeded in determining that at least 6.5 % of de novo mutations occur during the development of the child (post-zygotic) rather than from the germline of a parent.

Unlike whole - genome sequencing, this assay targets a select set of genes or regions with known associations with lymphoid cancer, allowing for more rapid detection of a variety of mutations.