Sentences with phrase «whole genomic sequencing»

For the study, which was published in Nature Communications, the group performed whole genomic sequencing on 30 individual tumors classified as liver cancer displaying a biliary phenotype.

Not exact matches

The country is offering whole genome sequencing to every citizen who wants it — a project that will chart the way for the future of genomic medicine.

Hur added, «To investigate whether Cpf1 had off - target effects, we performed whole genome sequencing using genomic DNA isolated from one Foxn1 mutant mouse and its wild - type sibling.

Cell - free genomic DNA isolated from human cells was cleaved with preassembled, recombinant Cpf1 RNPs and subjected to whole - genome sequencing.

They digested human genomic DNA using Cas9 nucleases in a test tube, which was then subjected by whole genome sequencing.

«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole - genome sequencing or just targeting some genomic regions with a gene baiting approach,» says Besnard.

It is now possible to perform whole - genome shotgun sequencing as well as capture of specific genomic regions for extinct organisms.

Currently, his group offers standard genomic services to investigators worldwide, including transcriptomics, whole exome sequencing, and epigenomics.

This is one of the first population genomics analyses to use high - coverage whole - genome sequencing in pigs, each individual has been sequenced more than 20-fold depth with the genome coverage of 95 %.

NEW YORK, July 11, 2017 / PRNewswire / — In a study published today in the July 11, 2017 issue of Neurology ® Genetics, an official journal of the American Academy of Neurology, researchers at the New York Genome Center (NYGC), The Rockefeller University and other NYGC member institutions, and IBM (NYSE: IBM) have illustrated the potential of IBM Watson for Genomics to analyze complex genomic data from state - of - the - art DNA sequencing of whole genomes.

The advent of accessible and relatively inexpensive high - throughput sequencing technology has resulted in extensive sequencing of whole human genomes or exomes in a research setting and seems likely to lead to an explosion of genomic sequencing in a clinical context.

Considerations of privacy and autonomy are being challenged on a massive scale by WGS and whole - exome sequencing (WES), technologies that are expected to contribute to our understanding of host genomics in the context of infectious disease.

We have generated rich genomic datasets for the scientific community, including an expansive atlas of genetic associations with metabolites, whole - genome sequence and phenotype data for population cohorts in the UK10K project, as well as bioinformatic resources to facilitate the retrieval of information, including a metabolite network, a database of genotype - metabolite associations with our colleagues at the HelmHoltz institute, and a genome browser of UK10K association results.

Finally, Eng described new genomics advances including whole genome sequencing for potential clinical application with its opportunity for changing the paradigm of healthcare and its multiple attendant challenges.

After this course you should be able to: - Prepare libraries from genomic DNA for amplicon or whole genome approaches to nanopore sequencing - Run ONT devices and assess sequencing performance during a run - Understand the basics of ONT data handling and analysis - Analyse and interpret ONT amplicon data and whole genomic data from bacterial samples

This month in Nature, researchers from BC Cancer Agency have characterized the landscape of genomic aberrations in 104 TNBC cases with a combination of whole - genome sequencing, exome sequencing, RNA - seq, and high - density SNP arrays.

Another distinctive genetic feature of mucosal melanoma is its high rate of copy number and structural variants, demonstrated both by array - based comparative genomic hybridization and whole - genome sequencing.

It is also recommended that the current voluntary restriction on insurers» ability to ask for predictive genetic test results should be renewed, in the light of public concerns over genomic data disclosure to insurers and the risk that this might result in many «refusing their consent to receive additional findings from whole genome sequencing».

Genomic Inheritances: Disclosing Individual Research Results From Whole - Exome Sequencing to Deceased Participants» Relatives The American Journal of Bioethics, 12 (10), 1 - 8 DOI: 10.1080 / 15265161.2012.699138

His laboratory has also discovered and characterized a significant number of novel genes contributing to autism and human neurodevelopmental disorders, and has recently applied whole - genome sequencing technologies and large - scale genomics datasets to prenatal detection and interpretation of structural variation in the genome.

In the last five years, major advances in genomic technology, especially in sequencing whole genomes and whole exomes (the portion of the genome that codes for proteins), have given rare disease research an important boost.

Elizabeth A. Winzeler of the University of California, San Diego, uses big data from whole - genome sequencing and genomics to identify novel drug targets and genes that contribute to pathogen drug resistance.

In short, genomic analysis (and especially whole - genome sequencing) is deeply informative for childhood cancers, and we should do a lot more of it.

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Using assembly - based whole - genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors.

Here we present a detailed comparison of the performance of all currently available whole genome sequencing platforms, especially regarding their ability to call SNVs and to evenly cover the genome and specific genomic regions.

As clinicians begin to consider whole - genome sequencing, an understanding of the processes and tools involved and the factors to consider in the annotation of the structure and function of genomic elements that might influence variant identification is crucial.

Whole genome sequencing and assembly of a Caenorhabditis elegans genome with complex genomic rearrangements using the MinION sequencing device

Targeted sequencing, in which only a selected set of genomic loci are sequenced, enables a much higher coverage of each target than what is obtained using whole genome or exome sequencing.

Together with Anna - Maria Divne, I am setting up and establish methods for single cell genomics, from single cell sorting, to whole genome amplification, target screening and sequencing library preparation.Why can you find me on this homepage?

The HudsonAlpha Clinical Services Lab, in collaboration with Illumina, serves as the whole genome sequencing core for the Undiagnosed Disease Network (UDN), a National Institutes of Health - funded study to diagnosed rare and new diseases through the use of genomics and other advanced technologies.

With the speed of genomic sequencing increasing at the same time as a rapid drop in pricing, whole genome sequencing (WGS) is rapidly becoming a preferred clinical laboratory test.

At the same time, genomic technologies such as NIPT, whole genome sequencing and genome editing are advancing to the point of imminent common use in clinical practice.