Sentences with phrase «whole tissue»

This is in contrast to conventional biochemistry and molecular biology, which focuses on analyses of whole tissue samples and whole microbial populations or communities.

A few years later, Karl Deisseroth's lab developed CLARITY, which is a hydrogel - based method that also allows antibody penetration for immunohistochemical labeling in whole tissue (15).

[25] Seeing that in metastatic patients the only available tumor is often core biopsies rather than whole tissue blocks, we next attempted to determine whether the degree of heterogeneity varies between primary and metastatic sites, using the TMA cores as surrogates for core biopsy specimens.

Camp and colleagues evaluated the correlation of TMAs to whole tissue sections and concluded that 2 separate cores allowed accurate assessment of protein expression, although this is clearly biomarker dependent, as heterogeneity varies from marker to marker [35].

These developments in microscopy coupled with techniques that make tissues transparent are enabling microscopes to visualize the cellular architecture of whole tissues in 3D with unprecedented detail.

It is now essential to find out how these fundamentally novel observations translate to whole tissue or organisms, to make us better equipped to influence them in complex organisms for future medical and agricultural purposes.»

For cells to have major functional differences they need to express many genes together that are specific to the function, which will be reflected on a whole tissue level.

Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.

For example, in the VNO the 14 most abundant genes account for almost 50 % of the fragments obtained from the whole tissue.

Whole tissue and glandular therapy supplementation may not be warranted when dealing with severe liver failure, kidney disease or acute infections.