Sentences with phrase «whole tumor model»
The next step for the researchers is to demonstrate the viability of this approach to the production and delivery of an anticancer molecule in a whole tumor model system.
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Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.
«This opens up a whole new field of being able to do personalized oncology where you can model human mutations and start treating tumors based on these mutations,» Papagiannakopoulos says.
Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.
PD - L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease.