In support of this hypothesis, the redox sensitivity of the basic insulin receptor signaling activity in vivo has been confirmed in a placebo - controlled clinical study of non-diabetic obese persons in
whom basic (i.e., post-absorptive) insulin receptor signaling
decreased after supplementation with relatively
small doses of N - acetyl cysteine (200 mg NAC t.i.d. for a total daily dose of 0.6 g for 8 weeks).27