A separate analysis showed a similar drop in netrin - 1 in affected neurons in rats
whose axons from the brain to the spinal cord had been cut.
We recently identified two MB output neuron (MBON) classes
whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep - promoting MBON class and a glutamatergic wake - promoting MBON class.
GenSight's treatment is for people with damaged photoreceptor cells but intact ganglion cells; it inserts the gene into the ganglion cells,
whose axons form the basis of the optic nerve.
However, in
those whose axons had been eliminated, there was no significant recovery.»
This recovery progressed in those mice
whose axons were not severed.
Glutamate indirectly activates the substantia nigra and ventral tegmental area, which contain cells
whose axons release dopamine in the hippocampus.
The VTA contains dopamine neurons
whose axons extend to many other regions of the brain.
Not exact matches
And in transgenic pups
whose optic nerves were surgically severed 4 days after birth, retinal
axons grew around the gap, finding their way to the proper target areas in the brain.
«This is not the first gene identified
whose loss protects mammalian
axons from degeneration,» DiAntonio says.
In another experiment, the researchers severed rodents» optic nerves — an act ordinarily lethal to RGCs,
whose outgoing fibers, called
axons, constitute the optic nerve.
«This is not the first gene identified
whose loss protects mammalian
axons from degeneration,» DiAntonio said.