For example, an andropausal man
whose serum test results indicate
total testosterone at normal levels may still be experiencing loss of muscle and libido, prostate enlargement, and erectile dysfunction, along with increased risk of cardiovascular disease, osteoporosis and depression, if most of his
testosterone is bound, which becomes increasingly likely in men > 50, the age at which
testosterone levels typically begin to decline, while levels of sex hormone binding globulin (SHBG) increase with age.14