For instance, Liu uncovered physical features of
rhinovirus C that help explain
why it is resistant to standard antiviral treatments, how it interacts with cells to cause infection, and
why it behaves as a different disease from other members of the enterovirus family.
This and other virus surface changes help explain
why clinical
rhinovirus drug trials, which rely on different virus surfaces, have generally failed when tested against
rhinovirus C isolates over the last four to five years, says Palmenberg.