Sentences with phrase «wide association analysis»

Genome - wide association analysis of copy number variation in recurrent depressive disorder.

To demonstrate the power of across breed mapping, three positive control traits, hyperuricosuria, white spotting and chondrodysplasia, were selected for genome wide association analysis.

We propose to use a technique called genome - wide association analysis to evaluate the differences in the genetic material of affected dogs (dogs infected with Aspergillus spp.).

Genome - wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.

The researchers say this is the first study to ever do such a genome - wide association analysis for an infectious disease.

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

Collaborative genome - wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Genome - wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci.

Conclusions / significance: This study is one of the first genome - wide association analyses in a parasitic nematode, and provides insight into the genomics of ivermectin response and population structure of O. volvulus.

We performed genome - wide association analyses for twenty serum biomarkers involved in organ function and reproductive health.

Molecular genome - wide association analyses have identified single nucleotide polymorphisms that segregate with the boldness - shyness axis in dogs [10, 11].

Not exact matches

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Researchers from Boston University School of Medicine looked for new stroke genes using genome wide association as well as meta - analysis.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such as gene sets produced from genome - wide association studies (GWAS) and differential expression analysis.

Their analysis also considered results from two earlier genome - wide association studies and confirmed certain previous findings.

Corresponding author, Dr Seth Weinberg says «Our analysis identified several genetic associations with facial features not previously described in earlier genome - wide studies.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

This issue was identified by follow - up on likely «false - positive» genetic associations with genome - wide statistical significance in case - control analysis.

Data generated in the lab have contributed to several international T2D consortia including the Meta - analysis of T2D in African Americans (MEDIA) Consortium that has performed meta - analysis of 17 genome - wide association studies (GWAS) for T2D in over 8,000 cases and 16,000 controls.

Genetic loci associated with plasma phospholipid n - 3 fatty acids: a meta - analysis of genome - wide association studies from the CHARGE Consortium

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Pathway - based analysis of a melanoma genome - wide association study: analysis of genes related to tumour - immunosuppression.

These webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis.

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

The webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis (Figure 1 - 2).

Sur I, Tuupanen S, Whitington T, Aaltonen LA, Taipale J. Lessons from Functional Analysis of Genome - Wide Association Studies.

Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication - based analysis for two - stage genome - wide association studies.

We performed a genome - wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass.

Veröffentlichung Q. Fan et al., Meta - analysis of gene - environment - wide association scans accounting for education level identifies additional loci for refractive error, Nature communications 7, 11008, 6.

220/2: 30 PolyTest: A novel method for joint analysis of genome - wide association studies and functional annotations.

This discovery approach greatly enhances the future potential of epistasis analysis for systems biology, and can complement genome - wide association studies as a means of formulating hypotheses for targeted experimental work.

The genes were identified through population - and genome - wide linkage scans and association analyses of at - risk haplotypes utilizing genetic and clinical data from the 17,000 participants in deCODE's obesity program in Iceland.

Information was extracted from a recent meta - analysis of five genome - wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed.

The paper, «Meta - analysis of genome - wide association studies of asthma in ethnically diverse North American populations» by Dara Torgerson et al., will be published online July 31, 2011 by Nature Genetics.

Here, Kiel and colleagues perform a meta - analysis of genome - wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

U.S. Travel Association: Covers a wide variety of travel - related topics, from impacts of travel on state economies to analysis of what a stronger dollar means for the travel industry.

Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large - scale genome wide association studies, gene - environement interaction studies, and pharmacogenetics.