Then, the researchers performed a so - called genome -
wide association study on the participants, searching for variations in a single DNA base correlated with these differences.
Again, putting aside questions about the accuracy or utility of this information, there is a lot of published scientific literature that is potentially relevant to people with a particular genotype (including genome -
wide association studies as well as a lot of classical human genetic literature and other functional studies).
Previous genome -
wide association studies using samples from individuals of African descent failed to detect any replicable genes associated with blood pressure.
The research team, following up on a previous genome -
wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.
The first, now completed, she describes as a «robust computational pipeline for translating genome -
wide association studies into real biological insights.»
Furthermore, a locus for the flank sucking behaviour, a compulsive behavioural disorder most often seen in Doberman Pinchers, was recently mapped to the gene cadherin 2 (CDH2) in a genome - wide association study [22].
Meta - analyses of genome -
wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.
A second, genome -
wide association study scanned the genome for common variants behind autism in more than 10,000 affected children, their families, and controls.
The researchers acknowledge the Ovarian Cancer Association Consortium and the Genetic Associations and Mechanisms in Oncology (GAME - ON): a National Cancer Institute
Post-Genome Wide Association Study Initiative (U19 - CA148112).
Biologist Steven Rose highlights a recent genome -
wide association study seeking genes associated with educational attainment (Science, vol 340, p 1467).
Because the gene for Ankyrin - G has popped up in several genome -
wide association studies combing human DNA for genetic risk factors of bipolar disorder, the researchers focused their attention on its role in the brain.
We also show that the results of genome
wide association studies appear to be qualitatively inconsistent with mutation - selection - drift equilibrium, assuming modern prevalence and fitness cost of disease, but that pleiotropy and / or very recent environmental change can potentially explain these inconsistencies.
Another way of looking at genome -
wide association study results is the so called pathway - based approach, which links SNPs considered mutually involved in a pathway.
In my last post, I reviewed a genome -
wide association study highlighting the importance of rare genetic variants in complex disease, specifically age - related macular degeneration (AMD).
First publication of genome -
wide association study leveraging deCODE's population approach; Finding to be integrated into deCODE's DNA - based diagnostics program A team of deCODE scientists, along with academic colleagues from the United States, Iceland, Spain and the...
ASHG 2008: Advancing Our Understanding of Genetic Disease: New Findings from Genome -
Wide Association Studies ASHG Press Release - November 12, 2008
Saturday, Oct. 21, 9:45 - 10:45 a.m., Room 220B, South Building Platform Session: Transcriptome -
wide Association Studies Moderators: Hae Kyung Im, University of Chicago; and Alexander Gusev, Harvard University
Genometric Analysis Simulation Program (GASP) Histone Sequence Database Homeodomain Resource Mnemiopsis Genome Project Portal r2VIM: A New Variable Selection Method for Random Forests in Genome -
Wide Association Studies Regression of Offspring on Mid-Parent (ROMP) Tiled Regression Analysis Package (TRAP)
A Novel Genome -
Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17.
Grant 01413 (2011) Investigation into the Genetics of Scottie Cramp: a Genome -
Wide Association Study Natasha J Olby; North Carolina State University Project Dates: 1/1/2011 to 3/31/2012 Sponsorship Payment: $ 23,250
Together with Drs. Mina Chung, Dave Van Wagoner, and John Barnard, we have performed a genome
wide association study for atrial fibrillation, and we are now working to determine how these common genetic variants act to alter susceptibility to this disease.
They created a score based on a combination of genetic variants identified by prior genome -
wide association studies as being associated with telomere length.
Most genetic analyses of heritable physical characteristics, including genome -
wide association studies in human populations, focus on so - called «additive» variants that have effects that occur regardless of the organism's genetic background.