Using an approach called a genome -
wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that
appear more often in people with the disease than in healthy individuals.
While those
studies identified several gene variants that
appeared to increase the risk of each disorder, none of the
associations were strong enough to meet the strict standards of genome -
wide significance.
Some groundbreaking findings from this
study appear in a recent paper in PLoS Genetics, «Genome - wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Gol
study appear in a recent paper in PLoS Genetics, «Genome -
wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Gol
Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Goldens.