This discovery approach greatly enhances the future potential of epistasis analysis for systems biology, and can complement genome -
wide association studies as a means of formulating hypotheses for targeted experimental work.
Again, putting aside questions about the accuracy or utility of this information, there is a lot of published scientific literature that is potentially relevant to people with a particular genotype (including genome -
wide association studies as well as a lot of classical human genetic literature and other functional studies).
«Our approach is likely to «revive» genome -
wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»
Not exact matches
Only 1 case - control
study from the Netherlands has reported results.262 This
study did not find an
association between usual digit - sucking (reported
as «thumb - sucking») and SIDS risk (OR: 1.38 [95 % CI: 0.35 — 1.51]-RRB-, but the
wide CI suggests that there was insufficient power to detect a significant
association.
The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known
as a genome -
wide association study.
The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such
as gene sets produced from genome -
wide association studies (GWAS) and differential expression analysis.
Genome -
wide association studies of eating disorders in humans have been limited in their power to detect significant
associations between genotype and disease or disease traits such
as binge eating.
Nestadt and his team conducted what is known
as a genome -
wide association study, scanning the genomes of more than 1,400 people with OCD and more than 1,000 close relatives of people with the mental disorder.
To reduce false positives when identifying genetic variations associated with human disease through genome -
wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility
as reported in Human Genetics on October 2, 2014.
These so - called genome -
wide association studies have turned up hundreds of genetic markers linked to diseases such
as cancer and diabetes.
This technique, known
as a genome -
wide association study, turned up two genetic variants.
Scientists for years have looked for the biological roots of the problem using tools such
as genome -
wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.
The project described in this proposal will help us to extend the findings from other genetics research, including GWAS (genome -
wide association studies) and in vitro
studies, into an in vivo investigation using mouse models in order to establish BIN1
as a potential new candidate in AD pathophysiology.
Genome -
wide association studies are a critical tool in the detection of genes involved in complex diseases such
as diabetes and cancer or traits such
as height and obesity.
APOE and BCHE
as modulators of cerebral amyloid deposition: a florbetapir PET genome -
wide association study.
CLU is a confirmed AD gene from genome -
wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention
as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).
Despite type 2 diabetes having been well
studied by genome -
wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11
as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
CONTEXT Genome -
wide association studies (GWAS) have recently identified CLU, PICALM, and CR1
as novel genes for late - onset Alzheimer disease (AD).
By examining the results of genome -
wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3
as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.
Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration
as identified by human genome -
wide association studies.
deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome -
wide association studies have confirmed
as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.
Rafnar T European genome -
wide association study identifies SLC14A1
as a new urinary bladder cancer susceptibility gene.
Researchers will use GTEx data to follow up on findings from genome -
wide association studies and
as a resource for the general
study of gene expression networks.
We undertook a genome -
wide association study (GWAS) in 142,487 individuals from the UK Biobank to identify loci associated with BMD
as estimated by quantitative ultrasound of the heel.
In addition, recent genome -
wide association studies have identified several hundred common genetic variants — inherited changes in the DNA sequence of the human genome — that play a role in an individual's susceptibility to complex human illnesses such
as heart disease, mental illnesses, cancer and diabetes.
Women may perceive men with
wider faces
as more dominant and more attractive for short - term relationships, according to a new
study in Psychological Science, a journal of the
Association for Psychological Science.
As mentioned above, some of these problems can be tackled by increasing study sizes and combining study samples, increasing the number of carefully chosen candidate polymorphisms or as Plomin and Davis suggest [81] employing the newly available genome - wide association (GWA) strateg
As mentioned above, some of these problems can be tackled by increasing
study sizes and combining
study samples, increasing the number of carefully chosen candidate polymorphisms or
as Plomin and Davis suggest [81] employing the newly available genome - wide association (GWA) strateg
as Plomin and Davis suggest [81] employing the newly available genome -
wide association (GWA) strategy.
We found no
associations between child involvement and other treatment variables, however, it is not entirely clear what role child and parent involvement played and it would be useful for
studies to look at the relative merits of child alone vs. family -
wide involvement in the FDP
as a measure of treatment outcome and process.
The results of the present
study suggest that the debate about the validity of cG × E (Duncan and Keller, 2011) and the preferred strategy of genome -
wide association studies, rather than
studies of candidate genes, merits nuance,
as these designs are complementary.