Sentences with phrase «wide association studies in»

Yet another primary interest is in the genetics of hearing and deafness disorders using mouse models of human deafness disorders and genome - wide association studies in age - related hearing impairment.

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

How many genome - wide association studies in the past two years were made possible by the human haplotype map?

The Wellcome Trust, the U.K.'s largest biomedical charity, began to put its weight behind genome - wide association studies in 2005 and recruited 200 researchers to analyze the DNA of 17,000 people from across the United Kingdom.

Grant 1591: Discovery of Genetic Susceptibility Loci in Atopic Dermatitis using a Genome - Wide Association Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disease.

Not exact matches

A new US study charting a 64 - year fall in the carbon footprint of producing milk in the country, reflects wider global success in adopting sustainable milk production, according to one national dairy association.

He has extensive experience in the wider agro-food sector and a wide interdisciplinary academic background covering fields of Food Technology, European studies, Wine Management and International Association Management.

An emerging body of literature in adults has begun to establish clear associations between gut microbiome composition and a wide range of health outcomes.1 - 6 In contrast, comparatively little is known about the gut microbiome in infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequencein adults has begun to establish clear associations between gut microbiome composition and a wide range of health outcomes.1 - 6 In contrast, comparatively little is known about the gut microbiome in infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequenceIn contrast, comparatively little is known about the gut microbiome in infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequencein infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequencein their size and scope, a number of studies have established associations between intestinal microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequencein infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequences.

In with respect to the quality of mother - infant relations, a prospective longitudinal study of around 1000 young New Zealanders found a small but significant association between breastfeeding duration and adolescents» perceptions of maternal care, with a longer duration of breastfeeding being associated with increased adolescent perceptions of maternal nurturance.9 This association persisted after statistical control for a wide range of the selection factors noted above.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioIn this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioin three loci associated with extrinsic epigenetic age acceleration.

The first environment - wide association study borrows from genomics to reveal new leads in major complex diseases

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»

In genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphismsIn genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphismsin genomes, so - called SNPs (single nucleotide polymorphisms).

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

In their investigations or so - called genome - wide association studies, the team of researchers compared the genetic profile of study participants to the forced vital capacity (FVC), a volume parameter of lung function.

A second, genome - wide association study scanned the genome for common variants behind autism in more than 10,000 affected children, their families, and controls.

Genome - wide association studies are notoriously weak in identifying variants that strongly determine our health.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Available in Volume 168, Issue 8 of the American Journal of Medical Genetics: Neuropsychiatric Genetics, the paper, titled, «Using the Coriell Personalized Medicine Collaborative Data to Conduct a Genome - Wide Association Study of Sleep Duration,» draws on data collected from Coriell study participants to establish its findStudy of Sleep Duration,» draws on data collected from Coriell study participants to establish its findstudy participants to establish its findings.

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.

According to the researchers, this is the first large - scale study employing epigenome - wide association (EWAS) studies — which look at chromosomal make - up and changes — in relation to the brain and Alzheimer's disease.

The researchers acknowledge the Ovarian Cancer Association Consortium and the Genetic Associations and Mechanisms in Oncology (GAME - ON): a National Cancer Institute Post-Genome Wide Association Study Initiative (U19 - CA148112).

«Together with a previously published genome - wide association study, our findings suggest that lower levels of WNT10A may contribute to male pattern baldness in some individuals.»

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AIn 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for Ain more than 5,500 African Americans identified two genetic risk factors for AD.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

In 2006 the American Psychological Association (APA) assembled a task force of researchers with wide - ranging expertise to evaluate all peer - reviewed studies published in English since 1989 (when the last such review was conducted) that compared the mental health of women who had an abortion with that of other womeIn 2006 the American Psychological Association (APA) assembled a task force of researchers with wide - ranging expertise to evaluate all peer - reviewed studies published in English since 1989 (when the last such review was conducted) that compared the mental health of women who had an abortion with that of other womein English since 1989 (when the last such review was conducted) that compared the mental health of women who had an abortion with that of other women.

The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent cohorts of patients with IBS and control subjects.

Fugger hopes that his team's study will also help to dispel the notion that genome - wide association studies will never offer much that can be used in patient care (see «Human genetics: Hit or miss»).

Genome - wide association studies of eating disorders in humans have been limited in their power to detect significant associations between genotype and disease or disease traits such as binge eating.

In their new study, the team performed a genome - wide association study (GWAS) on a cohort of 235 Labrador retrievers, together with an independent replication cohort.

The genome - wide association study, conducted by a UCL - led collaboration of 65 academics in 11 countries and funded by Alzheimer's Society and the Lewy Body Society, is published in The Lancet Neurology.

«Face shape is in the genes: Genome - wide association study identifies genetic variants that contribute to healthy facial traits.»

Corresponding author, Dr Seth Weinberg says «Our analysis identified several genetic associations with facial features not previously described in earlier genome - wide studies.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

In the meantime, the genetic linkage technique has largely been replaced with genome - wide association (GWA) studies.

In a 7 - year study at a Boston elementary school where half the students are English Language Learners (ELL), setting a school - wide goal of improved writing skills and using a genres - based instructional method improved the performance of ELL students on state and internal assessments, according to Boston College Lynch School of Education Professor Maria E. Brisk, who presents her findings today at the American Educational Research Association annual meeting.

Dav Doodnauth, an MD and CEO of LifeLine Labs in Lexington, also uses genome - wide association studies to produce his «Pegasus Profiles.»

The authors of the paper, which appears in the 29 August issue of PLoS Genetics, work on large genome - wide association studies.

To explore the genetic contribution, we undertook a genome - wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Called a genome - wide association study or GWAS, the method looks for signs that certain quirks in people's genomes are related to a trait.

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

But in the disease module, it was clear that some of those 182 genes were highly connected hubs in the social network, a state of affairs that a genome - wide association study alone is not equipped to reveal.

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.