Sentences with phrase «wide association studies including»

The researchers combined data from 22 genome - wide association studies including new data from around 35,000 migraine sufferers.

Not exact matches

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

The project described in this proposal will help us to extend the findings from other genetics research, including GWAS (genome - wide association studies) and in vitro studies, into an in vivo investigation using mouse models in order to establish BIN1 as a potential new candidate in AD pathophysiology.

Data generated in the lab have contributed to several international T2D consortia including the Meta - analysis of T2D in African Americans (MEDIA) Consortium that has performed meta - analysis of 17 genome - wide association studies (GWAS) for T2D in over 8,000 cases and 16,000 controls.

Mark McCarthy and colleagues combine genome - wide association study (GWAS) data for birth weight from 153,781 individuals representing multiple ancestries - including individuals of European, African American, Chinese, Filipino, Surinamese, Turkish and Moroccan - from a total of 37 studies.

The AA cohort has contributed to several consortia including: the International Consortium for BP Genome - wide Association Studies (ICBP - GWAS - Nature, 2011), the CARe AA cohorts for BP (Hum Mol Genet, 2011), and CARe for Renal Function (PLoS Genet, 2011).

With the aim of searching for sequence variants that predispose to SSS, a genome - wide association study was performed including 792 Icelanders with SSS and 37,592 Icelandic controls.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

Genome - wide association studies have revealed genomic regions associated with more than 200 diseases, including heart disease, diabetes and different types of cancer.

Again, putting aside questions about the accuracy or utility of this information, there is a lot of published scientific literature that is potentially relevant to people with a particular genotype (including genome - wide association studies as well as a lot of classical human genetic literature and other functional studies).

This includes Genome - Wide Association Studies (GWAS) to identify genetic loci associated with insecticide resistance and population genetic studies to describe population sub-strucStudies (GWAS) to identify genetic loci associated with insecticide resistance and population genetic studies to describe population sub-strucstudies to describe population sub-structuring.

Genome - wide association studies (GWAS) have detected association between variants in or near the Lysophospholipase - like 1 (LYPLAL1) locus and metabolic traits, including central obesity, fatty liver and waist - hip ratio.

Despite the significant insights gained from large - scale studies designed to interpret this instruction book, including HapMap, Encyclopedia of DNA Elements (ENCODE), and genome - wide association studies (GWAS), our knowledge of the human genome remains far from complete.

The Adverse Childhood Experiences (ACE) Study looked at over 17000 middle class, middle - aged Americans (average age in the 50s) and found dose - dependent associations between the number of adverse childhood experiences (see Table 1) and a wide array of outcomes, including markers for social functioning, sexual health, mental health, risk factors for common diseases, and prevalent diseases (see Table 2).4, 6 The retrospective ACE Study and several smaller but prospective studies indicate that adverse experiences in childhood influence behavior, mental wellness, and physical health decades later.1, 2,5,10