Sentences with phrase «wide association studies into»

The results of this study suggest that high - resolution fine - mapping in large samples can convert many discoveries from genome - wide association studies into statistically convincing causal variants, providing a powerful substrate for experimental elucidation of disease mechanisms.

Not exact matches

The project described in this proposal will help us to extend the findings from other genetics research, including GWAS (genome - wide association studies) and in vitro studies, into an in vivo investigation using mouse models in order to establish BIN1 as a potential new candidate in AD pathophysiology.

A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.

Genome - wide association scans with high - throughput metabolic profiling are powerful tools to study into how genetic variation influences metabolism and complex disease.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.

First publication of genome - wide association study leveraging deCODE's population approach; Finding to be integrated into deCODE's DNA - based diagnostics program A team of deCODE scientists, along with academic colleagues from the United States, Iceland, Spain and the...

131/5: 00 Phenome - wide association study provides biologic insights into the etiology of age - related macular degeneration.

We then imputed from these sequences into new and existing genome - wide association study cohorts and tested for association at ∼ 12 million variants in a total of 16,432 cases and 18,843 controls.

Conclusions / significance: This study is one of the first genome - wide association analyses in a parasitic nematode, and provides insight into the genomics of ivermectin response and population structure of O. volvulus.

Mapping hundreds of genetic variants through genome wide association studies provided an opportunity to gain insights into the pathobiology of immune mediated diseases.