Sentences with phrase «wide association studies using»

Genome - wide association studies use «genechip» technology to identify genetic variants (single gene polymorphisms or «SNPs») that could explain differences in health between individuals.

Not exact matches

The study used Mendelian Randomization (MR) techniques to examine publicly available data from genome - wide association studies.

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

Available in Volume 168, Issue 8 of the American Journal of Medical Genetics: Neuropsychiatric Genetics, the paper, titled, «Using the Coriell Personalized Medicine Collaborative Data to Conduct a Genome - Wide Association Study of Sleep Duration,» draws on data collected from Coriell study participants to establish its findStudy of Sleep Duration,» draws on data collected from Coriell study participants to establish its findstudy participants to establish its findings.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

Fugger hopes that his team's study will also help to dispel the notion that genome - wide association studies will never offer much that can be used in patient care (see «Human genetics: Hit or miss»).

In a 7 - year study at a Boston elementary school where half the students are English Language Learners (ELL), setting a school - wide goal of improved writing skills and using a genres - based instructional method improved the performance of ELL students on state and internal assessments, according to Boston College Lynch School of Education Professor Maria E. Brisk, who presents her findings today at the American Educational Research Association annual meeting.

Dav Doodnauth, an MD and CEO of LifeLine Labs in Lexington, also uses genome - wide association studies to produce his «Pegasus Profiles.»

Biologists typically look for genetic connections by using genome - wide association studies, which statistically associate genetic markers with disease.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

The project described in this proposal will help us to extend the findings from other genetics research, including GWAS (genome - wide association studies) and in vitro studies, into an in vivo investigation using mouse models in order to establish BIN1 as a potential new candidate in AD pathophysiology.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

Yet another primary interest is in the genetics of hearing and deafness disorders using mouse models of human deafness disorders and genome - wide association studies in age - related hearing impairment.

The sequencing work for this project has been done at the Wellcome Trust Sanger Institute, and the next phase of work is to develop a detailed catalogue of variants and a reference panel of quality - controlled genotyping data that can be used for accurate imputation in genome - wide association studies of malaria and other diseases.

The NASP output can be used for genome - wide association studies (GWAS) to correlate the genotype and phenotype, and can also be used for phylogenomics, which allows for an understanding of the relatedness of microbial isolates across temporal and spatial scales.

Such work has become increasingly important given the expansion of genome - wide association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

Researchers will use GTEx data to follow up on findings from genome - wide association studies and as a resource for the general study of gene expression networks.

During the past few years, various novel statistical methods have been developed for fine - mapping with the use of summary statistics from genome - wide association studies (GWASs).

We performed a genome - wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass.

These genes are usually found using genome wide association studies (GWAS) and GenoMEL is carrying out a very large study indeed.

Using individual - level data from 335,464 participants in the UK Biobank and summary association results from seven large - scale genome wide association studies, we examined the effect of this nitric oxide signaling score on cardiometabolic and other diseases.

Genome - wide association studies, or GWAS, are a popular method used by geneticists to find genetic variants associated with elevated risk for a particular disease.

While FDR is a well - recognized approach in biology, one could also argue for using a family wise error rate (FWER), which has been the norm in recent large - scale, genome - wide association studies (GWAS).

Grant 1591: Discovery of Genetic Susceptibility Loci in Atopic Dermatitis using a Genome - Wide Association Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the diseWide Association Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with tAssociation Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disStudy in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disewide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with tassociation study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disstudy of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disease.

Some researchers have argued that associations between abuse and adjustment problems can be explained by reporting biases because many studies of the effects of physical maltreatment use samples for which maltreatment is identified by referral to social service agencies.6 Of the community - wide population of maltreated children, those who are referred may represent a biased, more problematic subgroup.