Sentences with phrase «wide association study»

In search of genes associated with risk for psychopathic tendencies in children: a two - stage genome - wide association study of pooled DNA

Genome - wide association study of antisocial personality disorder.

Genome - wide association study of co-occurring anxiety in major depression.

No one has conducted a genome - wide association study of divorce (yet!)

These non-significant results are arguably due to the study's relatively small sample size for a genome - wide association study that requires multiple testing (ranging from N = 372 — 436 in the high and low trait comparison groups), making it unclear whether the same genetic variants are involved in these sub-domains.

Novel genes identified in a high - density genome wide association study for nicotine dependence

Grant 1591: Discovery of Genetic Susceptibility Loci in Atopic Dermatitis using a Genome - Wide Association Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disease.

Biopsy results from the affected puppy were sent to the University of California, San Diego - Comparative Neuromuscular Laboratory where an inflammatory and necrotizing myopathy of undetermined origin was concluded and a GWAS study (genome - wide association study) was recommended on their report of March 7, 2016.

Some groundbreaking findings from this study appear in a recent paper in PLoS Genetics, «Genome - wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Goldens.

A recent, first of its kind genome - wide association study of PCOS has identified two areas of DNA that leave women of European ancestry susceptible to developing PCOS.

Genome - wide association study of migraine implicates a common susceptibility variant on 8q22.1.

Methods: We did a genome - wide association study of 297 P falciparum isolates from Cambodia to investigate the relationship of 11 630 exonic single - nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in - vitro piperaquine 50 % inhibitory concentrations (IC ₅₀ s), and tested whether these genetic variants are markers of treatment failure with dihydroartemisinin - piperaquine.

179/5: 00 Genome - wide association study of olanzapine pharmacokinetics.

Wednesday, Oct. 18, 11:00 - 11:15 a.m., Room 310A, South Building Platform Presentation: Redrawing the map of blood pressure genes in a transcriptome - wide association study of over 301,000 participants in the Million Veterans Program and 145,000 from UK Biobank D.R. Velez Edwards, Vanderbilt University Medical Center, et al

We undertook a genome - wide association study (GWAS) in 142,487 individuals from the UK Biobank to identify loci associated with BMD as estimated by quantitative ultrasound of the heel.

We then imputed from these sequences into new and existing genome - wide association study cohorts and tested for association at ∼ 12 million variants in a total of 16,432 cases and 18,843 controls.

July 25, 2011 Two genetic variations predict second cancers after radiation treatment for children with Hodgkin lymphoma A genome - wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin's lymphoma are most likely to develop radiation - induced second cancers years after treatment.

Here, we present a large (n = 107,207) genome - wide association study (GWAS) of general cognitive ability («g»), further enhanced by combining results with a large - scale GWAS of educational attainment.

Objectives: To undertake a genome - wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity.

152/6: 15 Ancestry matched genome - wide association study identifies variants associated with spontaneous preterm birth.

131/5: 00 Phenome - wide association study provides biologic insights into the etiology of age - related macular degeneration.

Genome - wide association study (GWAS) data from a prospective cohort of warfarin - treated patients (n = 711) was also analyzed for genetic variations across the CYP4F gene cluster.

We performed a genome - wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass.

Genome - wide association study identifies sequence variants on 6q21 associated with age at menarche.

Genome - wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Rafnar T Genome - wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.

In the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophrenia.

First publication of genome - wide association study leveraging deCODE's population approach; Finding to be integrated into deCODE's DNA - based diagnostics program A team of deCODE scientists, along with academic colleagues from the United States, Iceland, Spain and the...

Rafnar T European genome - wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

Genome - wide association study of restless legs syndrome identifies common variants in three genomic regions.

for article Genome - wide association study identifies 74 loci associated with educational attainment.

A genome - wide association study of sleep habits and insomnia.

Genome - wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Genome - wide association study identifies a new melanoma susceptibility locus at 1q21.3.

The paper, «Genome - wide association study identifies sequence variants on 6q21 associated with age at menarche,» is published in the online edition of Nature Genetics, at www.nature.com/ng, and will be published in an upcoming print edition of the journal.

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

Genome - wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

In my last post, I reviewed a genome - wide association study highlighting the importance of rare genetic variants in complex disease, specifically age - related macular degeneration (AMD).

Genome - wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.

Pathway - based analysis of a melanoma genome - wide association study: analysis of genes related to tumour - immunosuppression.

Following up on findings from a an earlier genome - wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D.

Common genetic determinants of vitamin D insufficiency: a genome - wide association study.

Genome - wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Genome - wide association study identifies two novel Loci with sex - specific effects for type 2 diabetes mellitus and glycemic traits in a korean population

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

With the aim of searching for sequence variants that predispose to SSS, a genome - wide association study was performed including 792 Icelanders with SSS and 37,592 Icelandic controls.

A large genome - wide association study has identified eight new loci that confer susceptibility to osteoarthritis, researchers reported...

Another way of looking at genome - wide association study results is the so called pathway - based approach, which links SNPs considered mutually involved in a pathway.

Title: A genome - wide association study of a sustained pattern of antidepressant response Author: A. M. Hunter et al..