Sentences with phrase «wide association study by»

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.

Not exact matches

U.S. communities and states that have implemented alternatives to extended producer responsibility (EPR) policies are achieving high municipal solid waste recycling rates at reasonable costs, while also addressing a wider spectrum of the waste stream than narrowly - focused EPR mandates, according to a new study conducted by consulting firm SAIC for the Grocery Manufacturers Association (GMA).

Her work has been funded by several NIH agencies and her current study, funded by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program, examines the interaction between genome - wide association and social environmental factors related to blood pressure among African American hypertensive parents and early risks for high blood pressure among their untreated children.

This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.

The genome - wide association study, conducted by a UCL - led collaboration of 65 academics in 11 countries and funded by Alzheimer's Society and the Lewy Body Society, is published in The Lancet Neurology.

Motivated by the needs of current genome - wide association studies (GWAS), the study authors provide such a discussion.

Biologists typically look for genetic connections by using genome - wide association studies, which statistically associate genetic markers with disease.

Genome - wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small

How many genome - wide association studies in the past two years were made possible by the human haplotype map?

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

During her residency in Human Genetics at the University of Bonn she pursued her research interest both in immunology and human genetics by investigating expression quantitative trait loci (eQTLs), which underpin innate immune responses, and provide mechanistic insights to complement genome - wide association studies.

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.

Following up on findings from genome - wide association studies, researchers identify two mechanisms by which disruptions in the gene SLC16A11 may play a role in type 2 diabetes

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Following up on findings from a an earlier genome - wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D.

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

Catalyse a new generation of research on the genetic basis of drug resistance and of other forms of biological adaptation in pathogen populations, by providing a standard analytical framework for the design and interpretation of genome - wide association studies.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

This variant, identified by deCODE last year, has been confirmed in over 40 independent populations and has been shown to be the variant with strongest association to diabetes risk in five genome - wide association studies around the world.

deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome - wide association studies have confirmed as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.

Common risk alleles are often detected by genome - wide association studies (GWAS) 1,2.

Here, we present a large (n = 107,207) genome - wide association study (GWAS) of general cognitive ability («g»), further enhanced by combining results with a large - scale GWAS of educational attainment.

We undertook a genome - wide association study (GWAS) in 142,487 individuals from the UK Biobank to identify loci associated with BMD as estimated by quantitative ultrasound of the heel.

However, significant enrichments of genes whose proteins have roles in the extracellular matrix were amongst the top 300 genes with the most significantly associated NS SNVs, while regions associated with PD by a recent Genome Wide Association (GWA) study were enriched in genes containing PD - associated NS SNVs.

Genome - wide association studies, or GWAS, are a popular method used by geneticists to find genetic variants associated with elevated risk for a particular disease.

The paper, «Meta - analysis of genome - wide association studies of asthma in ethnically diverse North American populations» by Dara Torgerson et al., will be published online July 31, 2011 by Nature Genetics.

In our laboratory we study the relation between the genetic variation that were identified in genome - wide association studies (GWAS) or by whole exome / genome sequencing (WES / WGS) and the cardiac disease.

The findings by Anne McTiernan, M.D., Ph.D., and colleagues — from the first study to look at the impact of a wide range of self - monitoring and diet - related behaviors and meal patterns on weight change among overweight and obese postmenopausal women — are published online in the Journal of the Academy of Nutrition and Dietetics (formerly the Journal of the American Dietetic Association).

The Michigan Association of School Administrators released results from a State - wide study last month by the School Finance Research Collaborative examining school funding in Michigan that could change.

According to a study conducted by the Real Estate Association of Canada, there is a wide range of property taxes paid across the country.

British Columbia's model shows real promise by approving a wide range of development activities: from attending CLEs to publishing articles, from teaching law courses to being active in bar associations, from contributing to study groups to mentoring junior lawyers.

In a recent study, researchers strengthened the association between ACEs and mental health symptoms by adding such measures to the ACE index and removing parental separation / divorce and incarceration of a household member.28 Thus, the original index might be improved by considering a wider array of adverse experiences.

As mentioned above, some of these problems can be tackled by increasing study sizes and combining study samples, increasing the number of carefully chosen candidate polymorphisms or as Plomin and Davis suggest [81] employing the newly available genome - wide association (GWA) strategy.

Some researchers have argued that associations between abuse and adjustment problems can be explained by reporting biases because many studies of the effects of physical maltreatment use samples for which maltreatment is identified by referral to social service agencies.6 Of the community - wide population of maltreated children, those who are referred may represent a biased, more problematic subgroup.