Sentences with phrase «wide association study for»

Novel genes identified in a high - density genome wide association study for nicotine dependence

We performed a genome - wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass.

Here, Kiel and colleagues perform a meta - analysis of genome - wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

Not exact matches

U.S. communities and states that have implemented alternatives to extended producer responsibility (EPR) policies are achieving high municipal solid waste recycling rates at reasonable costs, while also addressing a wider spectrum of the waste stream than narrowly - focused EPR mandates, according to a new study conducted by consulting firm SAIC for the Grocery Manufacturers Association (GMA).

Her work has been funded by several NIH agencies and her current study, funded by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program, examines the interaction between genome - wide association and social environmental factors related to blood pressure among African American hypertensive parents and early risks for high blood pressure among their untreated children.

In with respect to the quality of mother - infant relations, a prospective longitudinal study of around 1000 young New Zealanders found a small but significant association between breastfeeding duration and adolescents» perceptions of maternal care, with a longer duration of breastfeeding being associated with increased adolescent perceptions of maternal nurturance.9 This association persisted after statistical control for a wide range of the selection factors noted above.

President of the Alumni Association of the National Institute for Policy and Strategic Studies (NIPSS), Mr. Khaled Bolaji has urged the Independent National Electoral Commission (INEC) to take advantage of the wide range of professionals its fold for electoral activities.

«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»

The basis for this project was the GWAS Catalog, where the results of all published genome - wide association studies are recorded.

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

A second, genome - wide association study scanned the genome for common variants behind autism in more than 10,000 affected children, their families, and controls.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such as gene sets produced from genome - wide association studies (GWAS) and differential expression analysis.

Genome - wide association studies are very interesting, but they are not some magic bullet for medicine.

The researchers say this is the first study to ever do such a genome - wide association analysis for an infectious disease.

Biologists typically look for genetic connections by using genome - wide association studies, which statistically associate genetic markers with disease.

Called a genome - wide association study or GWAS, the method looks for signs that certain quirks in people's genomes are related to a trait.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.

So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.

«A genome - wide association study of positive emotion identifies a genetic variant and a role for microRNAs.»

Many genome - wide association (GWA) studies are currently underway for identifying genetic elements involved in complex disorders.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

Data generated in the lab have contributed to several international T2D consortia including the Meta - analysis of T2D in African Americans (MEDIA) Consortium that has performed meta - analysis of 17 genome - wide association studies (GWAS) for T2D in over 8,000 cases and 16,000 controls.

Mark McCarthy and colleagues combine genome - wide association study (GWAS) data for birth weight from 153,781 individuals representing multiple ancestries - including individuals of European, African American, Chinese, Filipino, Surinamese, Turkish and Moroccan - from a total of 37 studies.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

The current SNP map now makes it possible for genome - wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

The AA cohort has contributed to several consortia including: the International Consortium for BP Genome - wide Association Studies (ICBP - GWAS - Nature, 2011), the CARe AA cohorts for BP (Hum Mol Genet, 2011), and CARe for Renal Function (PLoS Genet, 2011).

With the aim of searching for sequence variants that predispose to SSS, a genome - wide association study was performed including 792 Icelanders with SSS and 37,592 Icelandic controls.

Genome - wide association study identifies two novel Loci with sex - specific effects for type 2 diabetes mellitus and glycemic traits in a korean population

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

CONTEXT Genome - wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late - onset Alzheimer disease (AD).

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

Catalyse a new generation of research on the genetic basis of drug resistance and of other forms of biological adaptation in pathogen populations, by providing a standard analytical framework for the design and interpretation of genome - wide association studies.

Building on multiple genome - wide association studies, researchers identify a distant regulator of the EDN1 gene that influences risk for five vascular disorders.

Within this consortium, she has conducted genome - wide association scans for over 75,000 participants and has undertaken one of the first large - scale whole - genome sequencing studies for colorectal cancer, sequencing the whole genomes of 2,000 patients with colorectal cancer and 1,000 healthy control participants.

deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome - wide association studies have confirmed as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.

for article Genome - wide association study identifies 74 loci associated with educational attainment.

In the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophrenia.

The sequencing work for this project has been done at the Wellcome Trust Sanger Institute, and the next phase of work is to develop a detailed catalogue of variants and a reference panel of quality - controlled genotyping data that can be used for accurate imputation in genome - wide association studies of malaria and other diseases.

The NASP output can be used for genome - wide association studies (GWAS) to correlate the genotype and phenotype, and can also be used for phylogenomics, which allows for an understanding of the relatedness of microbial isolates across temporal and spatial scales.

Such work has become increasingly important given the expansion of genome - wide association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.

Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication - based analysis for two - stage genome - wide association studies.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.