Sentences with phrase «wide association study identifies»

Some groundbreaking findings from this study appear in a recent paper in PLoS Genetics, «Genome - wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers» (http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004922) From work performed in Dr Lindblad - Toh's lab, the investigators report that they have identified two loci that together contribute approximately 20 % of the risk of developing hemangiosarcoma and lymphoma in Goldens.

152/6: 15 Ancestry matched genome - wide association study identifies variants associated with spontaneous preterm birth.

Genome - wide association study identifies sequence variants on 6q21 associated with age at menarche.

Genome - wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Rafnar T European genome - wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

for article Genome - wide association study identifies 74 loci associated with educational attainment.

Genome - wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Genome - wide association study identifies a new melanoma susceptibility locus at 1q21.3.

The paper, «Genome - wide association study identifies sequence variants on 6q21 associated with age at menarche,» is published in the online edition of Nature Genetics, at www.nature.com/ng, and will be published in an upcoming print edition of the journal.

Genome - wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

Genome - wide association study identifies two novel Loci with sex - specific effects for type 2 diabetes mellitus and glycemic traits in a korean population

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

Genome - wide association study identifies shared risk loci common to two malignancies in golden retrievers.

«Face shape is in the genes: Genome - wide association study identifies genetic variants that contribute to healthy facial traits.»

Such work has become increasingly important given the expansion of genome - wide association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.

69/3: 00 Genome - wide association studies identify RAB38 and HS6ST1 associated with albuminuria in diabetes.

Not exact matches

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.

Genome - wide association studies are notoriously weak in identifying variants that strongly determine our health.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

Nestadt says the genome - wide association study findings of a PTRPD - OCD link add to evidence that the genetic region they identified is important.

Corresponding author, Dr Seth Weinberg says «Our analysis identified several genetic associations with facial features not previously described in earlier genome - wide studies.

To identify these variants, scientists performed a genome - wide association study.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.

Candidate gene and genome - wide association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

«A genome - wide association study of positive emotion identifies a genetic variant and a role for microRNAs.»

The NIA recently awarded a 5 - year, $ 19.5 million grant to the Alzheimer's Disease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's disease (AD).

While those studies identified several gene variants that appeared to increase the risk of each disorder, none of the associations were strong enough to meet the strict standards of genome - wide significance.

Many genome - wide association (GWA) studies are currently underway for identifying genetic elements involved in complex disorders.

When added to the samples from other sources, this will make available one of the largest collections of samples to perform genome - wide association studies (GWAS) in an effort to identify the susceptibility and protective genes influencing the onset and progression of late - onset disease.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

The current SNP map now makes it possible for genome - wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

A large genome - wide association study has identified eight new loci that confer susceptibility to osteoarthritis, researchers reported...

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.

Following up on findings from genome - wide association studies, researchers identify two mechanisms by which disruptions in the gene SLC16A11 may play a role in type 2 diabetes

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Genome - wide association studies have identified a firm link between the human FTO gene, obesity and type II diabetes.

Genome - wide association studies (GWAS) have been particularly effective in identifying multiple common variants with strong contribution to TGCT risk.

CONTEXT Genome - wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late - onset Alzheimer disease (AD).

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Building on multiple genome - wide association studies, researchers identify a distant regulator of the EDN1 gene that influences risk for five vascular disorders.