His work on statistical standards for genome -
wide linkage studies has transformed experimental design and become the gold standard for such experiments.
Leveraging deCODE's ability to conduct genome -
wide linkage studies using large extended families from across the population, the company's scientists were able to approach anxiety as a broadly defined disorder that encompasses all of these complexities.
Not exact matches
In the meantime, the genetic
linkage technique has largely been replaced with genome -
wide association (GWA)
studies.
Scientists for years have looked for the biological roots of the problem using tools such as genome -
wide association
studies and gene -
linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.
The deCODE
study is the largest population genetic
study ever carried out in patients with essential hypertension — high blood pressure without a known secondary cause — and reports the strongest genome -
wide linkage of any research on this condition to date.
Linkage disequilibrium may extend for megabases within some breeds, compared with only tens of kilobases in humans, making genome -
wide studies more economical in dogs [7].
Genetic research comprises formal genetic
studies, candidate gene
studies,
linkage analyses, and recently large - scale genome
wide association
studies, gene - environement interaction
studies, and pharmacogenetics.