Leveraging deCODE's ability to conduct genome -
wide linkage studies using large extended families from across the population, the company's scientists were able to approach anxiety as a broadly defined disorder that encompasses all of these complexities.
His work on statistical standards for genome -
wide linkage studies has transformed experimental design and become the gold standard for such experiments.
Not exact matches
In the meantime, the genetic
linkage technique has largely been replaced with genome -
wide association (GWA)
studies.
Scientists for years have looked for the biological roots of the problem using tools such as genome -
wide association
studies and gene -
linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.
The deCODE
study is the largest population genetic
study ever carried out in patients with essential hypertension — high blood pressure without a known secondary cause — and reports the strongest genome -
wide linkage of any research on this condition to date.
Linkage disequilibrium may extend for megabases within some breeds, compared with only tens of kilobases in humans, making genome -
wide studies more economical in dogs [7].
Genetic research comprises formal genetic
studies, candidate gene
studies,
linkage analyses, and recently large - scale genome
wide association
studies, gene - environement interaction
studies, and pharmacogenetics.