All of the above concerns with Cas9 activators are, for the most part, less of an issue in the setting of large scale genome -
wide screens as the only consequence of a gene not being properly up - regulated in this setting is a potentially missed hit rather than complete experimental failure.
Not exact matches
Onstream Meetings — This next app on the list contains a
wide range of features, such
as screen - and document - sharing, polling, shared controls, private chats and the option to add
as many
as 1000 attendees!
Wide angle cameras on the left and right hand side of the
screen track the presenter's face, automatically switching angles
as the presenter turns.
For example, if your company strategy is to increase sales by suggesting complementary products or services, remind your employees in seven different ways: In person, through your employee newsletter, via a company -
wide email blast, on a break room poster, through a voicemail blast, on a computer
screen saver and
as part of an employee quiz.
It also doubles
as a movie player — just point it at any blank wall for an instant
screen 10 - to 20 - feet
wide.
But I digress
as I strongly suspect you'll find weasel words to get out of following the example of early christians because then you'd have to give up your
wide screen TV.
He has a
wider screen and this issue has been happening to others
as well.
But see, instead of throwing him the
screens, they used all 5» 10, 185 pounds of Dorsett
as a blocker on
screens for other, lesser
wide receivers on their roster.
Here one can start the day with a «coretto» for courage (a heady mixture of coffee and grappa), then try such slopes
as the Forcella del Sasso Lungo — where you can see the world spread out in
wide screen — or the Val de Mesdi, so steep at the top (a 4,000 - foot drop in two miles) that you jump right out of your socks to make a turn.
Michigan moved Funchess around and employed a lot of different methods in order to get the ball to him, including quick 5 - yard stop routes
as well
as various
wide receiver
screens.
The Non-Invasive Prenatal Testing process, also referred to
as NIPT, offers peace of mind for many expecting parents by ruling out the need for invasive
screenings for a
wide range of chromosomal conditions including Down syndrome (Trisomy 21), Trisomy 18, Trisomy 13, and other fetal sex chromosome abnormalities.
(3) Neither the Executive Committee nor the County Leader shall designate, nominate or propose any candidate for judicial offices which are to be elected county -
wide in New York County, or which are to be proposed for appointment by the Mayor of the City of New York or by the Governor of the State of New York, exclusive of recommendations for interim appointment by the Mayor or the Governor, unless such candidate shall have been approved in that calendar year for such office by the independent panel., except that once a candidate for the office of Justice of the Supreme Court has been reported
as highly qualified by at least two of the last four independent
screening panels for that office, that candidate shall be considered
as having been approved by the panel for such office during each of the four calendar years after the year in which the candidate shall have last achieved such status, (not counting a year in which there are no vacancies for the office of Justice of the Supreme Court other than a vacancy resulting from the expiration of the term of office of a justice eligible for and seeking re-election to that office, or a vacancy which has been filled by an interim Supreme Court justice seeking re-election who has been appointed by the Governor and who satisfies the requirements of sub-paragraph 4 (b), provided in each case that such justice has been determined by the independent panel to merit continuation in office), and such candidate shall not make application to the panel during any of such years unless the Committee on the Judiciary shall require the candidate to make such an application.
But for elastography to work
as a population -
wide screening tool, the cost of using an MRI would have to be much lower.
However, there is
wide range of other employers working in forensic science, for example in drug
screening laboratories, and some graduates have chosen this
as a career.
It is being used
as a genome -
wide tool, to search thousands of genes in a cell and
screen for their function.
They wiggle across a computer
screen displaying real - time video from a gigantic microscope — a tall, beige tube about
as wide as a telephone pole.
«
As part of the RIPE project, we are
screening a
wide range of species from across the globe, and aim to identify variation that will enable improving photosynthesis and biomass production in rice, cassava and soybean.»
By performing a genome -
wide screen in breast cancer cells, Dr. Oesterreich and her colleagues identified a gene called HOXC10
as one that the cancer seems to modify to allow continued tumor growth in patients whose cancer becomes resistant to traditional therapies.
The latest TV
screens have a ratio of 16:9, the shape of modern cinema
screens, but
as most people still have 4:3
screens broadcasters seldom transmit new
wide -
screen programme material.
But
as the beam scans the edge areas of the
wide screen on either side of the central area, it accelerates.
«We've now devised a technology where we can effectively treat the surface of living mouse embryos
as a petri dish of cells, and carry out genome
wide screens on mouse cells in their native environment in vivo,» says Fuchs.
«Previously, genome -
wide screens were only possible in lower animals, such
as flies, worms and yeast, where it is often difficult to assess the relevance to human disorders such
as cancer.»
Dubbed
as the material of the future, graphene exhibits unique electronic properties that can potentially be employed for a
wide range of applications such
as touch
screens, conductive inks and fast - charging batteries.
The discovery may open the door not just to reading out smaller data bits, but also to a
wide range of improved magnetic technologies such
as making cheaper touch
screen displays.
Canon's latest prototype has pixels
as small
as 0.2 millimetres; a 38 - centimetre
screen is therefore 1280 pixels
wide and 1024 pixels tall.
The home has the usual appurtenances of the writerly life, with crammed bookshelves and curios of achievement, but also the perquisites that a reliable perch on the best - seller lists can confer, such
as the Panasonic
wide -
screen television, the office assistant on call in a nearby room, even the six - inch - thick slab of 150 - million - year - old Jurassic limestone in the garden, an impression of a dinosaur footprint on its underside, that occasionally serves
as a writing desk.
• Mutation
screening The unit can provide custom made assays for a
wide range of known mutations associated with disease, such
as single point mutations, insertions / deletions and sequence amplifications.
The adaptation of xenopus model to new technologies such
as customized nucleases and automated
screening tools, enables a
wider use of the amphibian model.
Title: A genome -
wide screen in EpiSCs identifies Nr5a nuclear receptors
as potent inducers of ground state pluripotency Authors: Guo G, Smith A Date: October 2010 Publication Details: Development.
Title: A genome -
wide RNAi
screen reveals MAP kinase phosphatases
as key ERK pathway regulators during embryonic stem cell differentiation (IN PRESS, Oct 2012) Authors: Sharrocks A, Yang S - H, Kalkan T, Haslam C, Smith A Date: IN PRESS, Oct 2012 Publication Details: PLoS Genetics
We employ a
wide variety of state - of - the - art technologies such
as in vivo optical imaging and high - throughput methods including cell - based
screening, genomics, and proteomics approaches.
Here we show that loss of the BLM helicase complex suppresses FANCC phenotypes and we confirm this interaction in cells deficient for FA complementation group I and D2 (FANCI and FANCD2) that function
as part of the FA I - D2 complex, indicating that this interaction is not limited to the FA core complex, hence demonstrating that systematic genome -
wide screening approaches can be used to reveal genetic viable interactions for DNA repair defects.
Furthermore, a genome -
wide forward
screen with Haplobank identified PLA2G16
as a host factor that is required for cytotoxicity by rhinoviruses, which cause the common cold.
Here, through a genome -
wide CRISPR - Cas9 - mediated forward genetic
screen, we identified MORC2
as an essential gene required for epigenetic silencing by the HUSH complex.
Supported by the resource of more than 42 000 unique human protein fragments generated within the Human Protein Atlas, representing more than 18 000 human protein coding genes, we offer proteome
wide screening for autoantibody reactivity, on the,
as well
as downstream solutions for investigation of autoimmunity in hundreds of patient samples in parallel.
Once I read that the American Pediatric Association were recommending
wider cholesterol
screening for children and more aggressive use of cholesterol - lowering drugs like Statins, starting
as early
as the age of 8 in hopes of preventing adult heart problems I hit the roof.
I am opening my mouth
wide open
as if I could eat the chicken from the
screen..
This application works fine on Android
as well
as iOS platform so anyone can enjoy a
wide range of dating features with few swipes on the
screen.
It's increasingly hard to remember a time when every superhero film made wasn't made
as part of a
wider universe,
as instalments in an ever - growing web designed to bring the head - scrambling continuity of comics to the big
screen.
DICK DINMAN & EDDIE MULLER DISPENSE A DOUBLE DOSE OF DANA: The Warner Archive has just released on Blu - ray legendary director Fritz Lang's last two American - made edge - of - your - seat thrillers WHILE THE CITY SLEEPS and BEYOND A REASONABLE DOUBT in their original
wide screen SuperScope incarnations and popular film noir author and TCM host Eddie Muller rejoins producer / host Dick Dinman
as they both salute the unjustly underrated star of both films, Dana Andrews.
Four years later, in 1963, Robert Wise directed The Haunting, a
wide -
screen, black - and - white movie based on Jackson's book, with Julie Harris and Claire Bloom memorable
as a pair of psychic women who visit a haunted house in New England.
The film, which stars Smith and Joel Edgerton
as a human - orc buddy cop duo, is the streaming giant's first attempt a major tentpole release, entering the kind of waters that are normally reserved for traditional studios opening films
wide across hundreds of cinema
screens.
He got rave reviews for his dual performance (and directing duties) on the HBO drama The Deuce and is set to wow audiences with The Disaster Artist, which opens in U.S. cinemas this weekend
as well
as on selected UK
screens (it opens
wide here next week).
They really need to lose the illogical portrait orientation on these ports,
as it makes them look bizarre (the human eye sees
wider than it does tall, hence the ratio of cinema and TV
screens), and feel uncomfortable to play.
In a
wide - ranging career across stage and
screen, Finlay starred
as Porthos in the Three Musketeer films of the 1970s, alongside Oliver Reed, Richard Chamberlain and Michael York
There are plenty of nits that can be picked with Fortified such
as the lack of split -
screen play, the aforementioned issue with not being able to place defenses within a
wide range of the base, and the level of difficulty for solo play.
Whether you chose the
wide or full
screen presentations, the disc offers a new animated short: Mater and the Ghostlight
as well
as the Academy Award - nominated animated short: One Man Band.
The later sequences are shot with
wider -
screen lenses, looking more like a modern blockbuster with every jump forward in time even
as Shen's life begins to feel more limited and frustrating.
Most of the bosses take up a large portion of the
screen and perform a
wide array of interesting attacks
as you run around trying to figure out how to hurt them.
This isn't a
wide screen release at all, and at times it seems
as if it was sourced from a pan?