Sentences with phrase «wide studies implicate»

Most genome - wide studies implicate massive regions, containing tens of thousands of letters, associated with disease.

Not exact matches

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

Genome - wide association studies have implicated hundreds (if not thousands) of new loci in common complex disease.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

It's no secret that while genome - wide association studies (GWAS) have implicated thousands of genetic loci in human phenotypes, the variants uncovered collectively explain only a fraction of the observed variance between individuals.

This study was aimed at understanding the genome - wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa.

100/2: 45 Genome - wide interaction study of Parkinson disease and vitamin D deficiency implicates immune system pathways.

Genome - wide association studies (GWAS) of common variants have successfully implicated more than 70 genomic regions in type 2 diabetes, revealing new biological pathways and potential drug targets.

Genome - wide association study of migraine implicates a common susceptibility variant on 8q22.1.

Studies demonstrating this greater susceptibility of neurobiologically responsive children to both positive and negative aspects of their environments have implicated a wide variety of stressors and adversities, including paternal depression (67), marital conflict (68, 69), parental psychopathology (70), and overall family distress (71); of positive environmental features, including parental warmth (72) and supportive interventions (73); and of defining biological parameters, including physiological reactivity (e.g., 74, 75), differences in brain circuitry (76), and gene polymorphisms (77, 78).