Sentences with phrase «wide study identifies»

135/6: 00 Exome - wide study identifies loci displaying pleiotropic associations with multiple cardiometabolic traits in continental Africans.

Not exact matches

In 2008, Starbucks conducted a company - wide compensation study that included regular salary check - ins to identify and address pay disparities.

With case studies, educational sessions, peer - to - peer conversations, and new technologies, we will provide a wide range of applicable, real world solutions to identified needs and situations for the food community.

Although continuity of care has been identified as a core component of a model of midwife - led care, there is wide variation in the definition and measurement of continuity of care which will require greater sophistication in future studies.

The temptation to identify as a specialist of a particular area is difficult for political geographers to resist; yet area studies has been vociferously criticised, particularly for its Western - centric perspective on viewing the wider world.

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Genome - wide association studies are notoriously weak in identifying variants that strongly determine our health.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

The study identifies a wide set of genes — previously associated with complex structures in higher animals — which were supposedly absent in sponges.

All this video needs to be studied, but the organization's software is not yet sophisticated enough to automatically identify a wide variety of animals and other features.

The study was the first of its kind to employ genome - wide reverse engineering to identify the gene pathways that contribute to periodontitis.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

Findings from this UK cohort are confirmed by evidence for adult - onset ADHD world - wide: a study from Brazil will be published by JAMA Psychiatry alongside this research, which also identified a large proportion of adults with ADHD as not having the disorder in childhood.

«This is the first genome - wide study to use bioinformatics and clinical information to systematically identify one lncRNA, which we found to be oncogenic,» Zhang says.

While direct measures such as emergency preparedness and the strengthening of response - related institutions is helpful, this study has identified the need for a wider cultural shift to ensure the poorest and most vulnerable are properly protected.

«In the current study, using a genome - wide analysis of DNA methylation, we identified a few PPARα target genes that underwent ligand - activated PPARα - dependent DNA demethylation during the perinatal period and whose DNA methylation status persists into adulthood,» explains a corresponding author Koshi Hashimoto.

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

In addition, we sought to identify modifiable predictors of CRC screening in non-African American and African American veterans by using a conceptual framework accounting for a wide range of clinical and demographic characteristics,» said study lead author Fola May, MD, MPhil, VA Greater Los Angeles Healthcare System.

Nestadt says the genome - wide association study findings of a PTRPD - OCD link add to evidence that the genetic region they identified is important.

«Face shape is in the genes: Genome - wide association study identifies genetic variants that contribute to healthy facial traits.»

Corresponding author, Dr Seth Weinberg says «Our analysis identified several genetic associations with facial features not previously described in earlier genome - wide studies.

To identify these variants, scientists performed a genome - wide association study.

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

In addition to identifying a gene that raises risk for colorectal cancer from eating red or processed meat, the study — the first to identify the interactions of genes and diet on a genome - wide scale — also reveals another specific genetic variation that appears to modify whether eating more vegetables, fruits and fiber actually lowers your colorectal cancer risk.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

«This was what you call a sort of fast - track phase,» Hakonarson says about the new study, in which he and his team identified and characterized only the strongest signals in the genome - wide analysis.

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

In a previous study, Lonard and co-senior study author Bert O'Malley of Baylor College of Medicine screened a large number of compounds to identify SRC - inhibiting molecules that kill a wide variety of cancer cells and inhibit tumor growth in animal models.

So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.

Candidate gene and genome - wide association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

Genome - wide association study identifies shared risk loci common to two malignancies in golden retrievers.

«A genome - wide association study of positive emotion identifies a genetic variant and a role for microRNAs.»

The NIA recently awarded a 5 - year, $ 19.5 million grant to the Alzheimer's Disease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's disease (AD).

While those studies identified several gene variants that appeared to increase the risk of each disorder, none of the associations were strong enough to meet the strict standards of genome - wide significance.

Many genome - wide association (GWA) studies are currently underway for identifying genetic elements involved in complex disorders.

Model intercomparison studies (e.g., Gregory et al., 2005; Rahmstorf et al., 2005; Stouffer et al., 2006) were developed to identify and understand the causes for the wide range of MOC responses in the coupled models used here (see Chapters 4, 6 and 10).

When added to the samples from other sources, this will make available one of the largest collections of samples to perform genome - wide association studies (GWAS) in an effort to identify the susceptibility and protective genes influencing the onset and progression of late - onset disease.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

The current SNP map now makes it possible for genome - wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

A large genome - wide association study has identified eight new loci that confer susceptibility to osteoarthritis, researchers reported...

By carrying out a genome - wide association study that took into account whether or not a person has faced a major adversity in their life, the scientists were able to identify contributing molecular mechanisms that not previously been associated with depression.