Sentences with phrase «wide study of disease»

In a pioneering study, he applied these tools to a genome - wide study of disease - related changes in the epigenome — the layer atop the genome that controls gene activity and is altered by the environment — of immune cells isolated from patients with asthma.

Not exact matches

Studies have shown that their wide array of antioxidants actually inhibit the growth of cancer cells, as well as protecting the body from cardiovascular disease — orange vegetables have been shown to provide the most protection against this disease.

A study published in Natural Product Reports in 2011 further described curcumin as being therapeutic for a wide range of diseases, including:

Through continued study, breastmilk has been shown repeatedly to have a wide array of effectiveness against disease - causing agents and lead to an overall positive immunological effect on the health and well being of the infant and mother.

Trials around the world are studying umbilical cord blood's capabilities in a wide range of diseases (see Table 2 here): Cerebral palsy, autism, diabetes and lupus are currently under investigation.

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

There's also a more recent foray into the study of complex biological systems, from the population - wide dynamics of a disease outbreak to the way human bodies align their functions to a biological clock.

Previous studies have shown links between human gut bacteria and increased risk of a wide variety of diseases including diabetes, autism, heart disease, and even some forms of cancer.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

The study is based on an analysis of 7,217 Finnish patients with Alzheimer's disease, whose use of antipsychotics was investigated as part of the Finnish MEDALZ - 2005 Study comprising nation - wide register study is based on an analysis of 7,217 Finnish patients with Alzheimer's disease, whose use of antipsychotics was investigated as part of the Finnish MEDALZ - 2005 Study comprising nation - wide register Study comprising nation - wide register data.

A new study finds a wide range of epigenetic changes — alterations in DNA across the genome that may be related to key environmental exposures — in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA).

And large, genome - wide studies searching for genetic underpinnings for more common diseases, such as lung cancer or autism, have pointed to the nether regions of the genome between the protein - producing genes — areas that were often thought to contain «junk» DNA that was not part of the pantheon of known genes.

Data from this study were obtained from the Compressed Mortality File (CMF) administered by the Office of Analysis, Epidemiology, and Health Promotion of the National Center for Health Statistics, Centers for Disease Control and Prevention (CDC), and the Internet - based CDC WONDER, a wide - ranging online data epidemiologic research system.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

At ABclonal, we have nearly 100 existing chromatin immunoprecipitation (ChIP)- validated antibodies with a higher specificity than most commercial antibodies, which are used for a wide range of epigenetics studies, from those investigating developmental processes to those researching various diseases.

Genome - wide association studies, which try to find correlations between particular genetic variations and disease diagnoses, are a staple of modern medical research.

The study has wide reaching implications for understanding the evolution of the human oral microbiome and the origins of periodontal disease.

Genome - wide association studies of eating disorders in humans have been limited in their power to detect significant associations between genotype and disease or disease traits such as binge eating.

Scientists studying brain diseases may need to look beyond nerve cells and start paying attention to the star - shaped cells known as «astrocytes,» because they play specialized roles in the development and maintenance of nerve circuits and may contribute to a wide range of disorders, according to a new study by UC San Francisco researchers.

Uncovering the genetic pathogenesis of Alzheimer's disease has been a target of great interest over the past few years, and genome - wide mapping studies focusing on risk genes have led to significant advances in the field.

«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.

Most genome - wide studies implicate massive regions, containing tens of thousands of letters, associated with disease.

A study published in PLOS Neglected Tropical Diseases collates a history of the disease and finds that while rates dropped world - wide in the post-penicillin era after 1945, they remained, up until recently, much higher in Sub-Saharan Africa compared with other regions.

These so - called genome - wide association studies have turned up hundreds of genetic markers linked to diseases such as cancer and diabetes.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

But in the disease module, it was clear that some of those 182 genes were highly connected hubs in the social network, a state of affairs that a genome - wide association study alone is not equipped to reveal.

Genome - wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small

In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.

BETHESDA, Md., Wed., Oct. 5, 2005 - The National Institutes of Health (NIH) today announced contracts that will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome - wide library of knockout mice.

A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.

The NIA recently awarded a 5 - year, $ 19.5 million grant to the Alzheimer's Disease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's diseasDisease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's diseasedisease (AD).

Nanoparticles are being studied as drug delivery systems to treat a wide variety of diseases.

When added to the samples from other sources, this will make available one of the largest collections of samples to perform genome - wide association studies (GWAS) in an effort to identify the susceptibility and protective genes influencing the onset and progression of late - onset disease.

MyBioSource has worked hard to provide a variety of products, including monoclonal antibodies that are reactive with a wide variety of species and can be used to study various disease states and physiological pathways.

I now find that this broad experience allows me to link ideas and observations together to have better insight into the disease, and enabled me to address technical challenges and limitations using a wide range of tools, some of which have not been applied to studies of neurodegenerative disease.

Genome - wide association studies are a critical tool in the detection of genes involved in complex diseases such as diabetes and cancer or traits such as height and obesity.

Finally, our study highlights the importance of epigenetics in T2D as adipose tissue from unrelated subjects with the disease exhibit genome - wide methylation changes.

Large genome - wide association studies are underway in a variety of diseases to determine what genetic abnormalities might be at play.

Researchers now routinely create induced pluripotent stem cells to study the biology of a wide range of diseases and to develop experimental medical treatments.

Genome - wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Genome - wide association studies (GWAS) have yielded increasing numbers of disease - associated candidates in recent years.

In my last post, I reviewed a genome - wide association study highlighting the importance of rare genetic variants in complex disease, specifically age - related macular degeneration (AMD).

Genome - wide association studies have implicated hundreds (if not thousands) of new loci in common complex disease.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

«What can genome - wide association studies tell us about the genetics of common disease?»

Also of wide impact have been Goldberg's studies showing that the ubiquitin proteasome pathway is critical in the clearance of misfolded proteins and in muscle atrophy in many disease states, as well as in antigen presentation to the immune system.

The sequencing work for this project has been done at the Wellcome Trust Sanger Institute, and the next phase of work is to develop a detailed catalogue of variants and a reference panel of quality - controlled genotyping data that can be used for accurate imputation in genome - wide association studies of malaria and other diseases.

Genome - wide association studies have revealed genomic regions associated with more than 200 diseases, including heart disease, diabetes and different types of cancer.