Sentences with phrase «widely studied model»

Not exact matches

This study, reported in the February 2015 issue of Experimental Biology and Medicine, utilized cultured cerebellar granule neurons, one of the most widely used models to study neuronal death.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

He presented his idea one day to a roomful of about 30 colleagues at Yale's «Worm Meeting,» the weekly gathering for researchers studying C. elegans, the lowly nematode widely used as a model organism in developmental biology.

Previous modeling studies have suggested widely different findings.

Analyses were performed on the frog Xenopus laevis, an animal model widely used by researchers from around the world to study laws governing cellular division in depth.

The study compared the effectiveness of the new tracer with 11C - choline (already widely used for imaging prostate cancer) in two mouse models and also performed the first PET / CT scan with 11C - sarcosine of a human with prostate cancer.

The team of Luis Lopez - Molina, professor at the Department of Botany and Plant Biology of UNIGE's Faculty of Science, Switzerland, has been interested for a long time in the mechanisms controlling germination, arguably the most critical decision in the life of a plant: «We have discovered that the genes involved in the synthesis of cutin, a waterproof substance, are important for the maintenance of dormancy in seeds of Arabidopsis thaliana, a small plant widely used as a model organism to study plant biology.

However, the quantitative response to freshwater inputs varies widely among models (Stouffer et al., 2006), which led the CMIP and Paleoclimate Modelling Intercomparison Project (PMIP) panels to design and support a set of coordinated experiments to study this issue (http://www.gfdl.noaa.gov/~kd/CMIP.html and http://www.pmip2.cnrs-gif.fr/pmip2/design/experiments/waterhosing.shtml).

We tested R6 / 2 transgenic mice, a widely used genetic model of Huntington's disease (Mangiarini et al., 1996), in two studies designed to evaluate progression of the disease phenotype with age.

The availability of a new and improved P. cynomolgi reference genome sequence will enable in - depth studies of this widely used model parasite, including investigations into dormant stages and the selection of new drug targets and vaccine candidates.

In this study, we utilized the scopolamine model to compare J147 to donepezil, the currently most widely used AD drug.

The fruit fly, Drosophila melanogaster, is widely used as a model organism for biological and biomedical research and so such puppetry should allow the species to be studied more easily than ever before.

Studies highlighting sex dimorphism and exploring pathophysiological mechanisms in animal models or humans are widely missing.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

The researchers studied all 571 European cities to assess the likely impact of flooding, drought and heatwaves in the latter half of the century, under a climate model where average temperatures rise between 2.6 C and 4.8 C - the current widely accepted business - as - usual trajectory.

Although the authors caution that their results are approximations intended to guide future modeling efforts, this study provides fundamental information regarding the relative difficulty of achieving desired albedo modification effects and is an important starting point for understanding the limits of what is widely considered one of the most viable solar geoengineering techniques.

To begin to test this hypothesis, we first used primary cultures of the E14 rat ventral midbrain (VM), which are an experimental tractable model of mDA neurons that are widely used to study the molecular mechanisms regulating mDA neurite growth [18].

Loss - of - function studies are key for investigating gene function, and CRISPR technology has made genome editing widely accessible in model organisms and cells.

Consequently, alternate - day fasting is a widely used model for studying the effects of calorie restriction in rodent species (15).

Hence, we feel that the most important result of the study of Stainforth et al. is that by far most of the models had climate sensitivities between 2ºC and 4ºC, giving additional support to the widely accepted range (Update: As mentioned in the follow up post, this clustering is mainly a function of the sensitivity of the original model and the random nature of the perturbations).

Although the atmosphere has been widely studied and modelled (particularly by weather forecasters), large uncertainties remain concerning climate variability.

National Academies publications based on publicly - funded studies, which should be readily and widely available in the U.S. and abroad, have had their circulation limited by a National Academies Press business model that combined the sale of sometimes pricey books with cumbersome online reading and printing arrangements.

«Instead of averaging the model forecasts to get a result whose surface trends match reality, the earlier study looked at the widely scattered range of results from all of the model runs combined.

Because the alleged IPCC «consensus» is so widely trusted, many climate scientists who haven't studied man - made global warming theory or the predictions of the computer models assume that they must be reliable merely «because the IPCC says so», rather than checking for themselves.

The IMPLAN and REMI models, widely used to study employment impacts, both projected that Arizona would gain about 8,000 net new jobs from this package; STAMP estimated a net loss of about 9,000 jobs.

Model performance varied widely across the study region.

The bottom line of the Bond et al. study is that the relative impact of anthropogenic carbon dioxide emissions is much less than widely thought, the relative impact of black carbon is greater than thought, and climate models» views of the past and projections of the future must therefore be tainted.

The simulations were produced using a widely - used weather prediction model coupled to a global model developed by NASA's Goddard Institute for Space Studies.

While the study's authors argue that «modeling tax changes as a substitute for quantifying the economic impact of regulatory proposals is a widely accepted practice,» they offer no analysis whatsoever to back up their assumption that the regulations at issue impose an implicit tax anywhere near that size.

It is now widely accepted that monkeys exposed to early life adversity in the form of experimental social rearing serve as reliable models for the study of anxious and depressive behaviors in children with insecure attachments (Barry et al. 2008; Bretherton 2000; Dettmer et al. 2014; Kalin and Shelton 2003; Kraemer 1997; Passman and Weisberg 1975; Suomi 2005).

IRT is a family of associated mathematical models that relate latent traits (ability) to the probability of responses to items in an assessment, and it has been widely used in health assessment.37, 38 It describes a nonlinear relationship between binary, ordinal or categorical responses and the latent trait (mental / behavioural problems in this study).

His efforts resulted in the establishment of Trauma Center, that consist of a well - trained clinical team specializing in the treatment of children and adults with histories of child maltreatment, that applies treatment models that are widely taught and implemented nationwide, a research lab that studies the effects of neurofeedback and MDMA on behavior, mood, and executive functioning, and numerous trainings nationwide to a variety of mental health professional, educators, parent groups, policy makers, and law enforcement personnel.

One of the most widely encouraged leadership models that managers use may not be effective in motivating agents or employees after they fail, according to the study.