Sentences with phrase «wild mice as»

To further validate AH10 - 7's effectiveness, the researchers tested the new compound in wild mice as well as partially «humanized» mice, whose genomes were modified to mimic the human iNKT cell response.

Not exact matches

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

More inflammatory - type T cells and less tolerant - type T cells were found in the colon of mice without gp96 as compared to wild - type mice.

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

If a mouse in the wild senses danger by smell, for example, it may freeze and slow down breathing as a survival instinct.

This is because, on treating with the antibiotic ampicillin, no inflammation was observed in wild - type SPF mice with the induction of TH1 cells as described above, but it was caused in IL (interleukin)-10-deficient SPF mice.

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

Next, they showed that deer mice and oldfield mice build the same kinds of burrows in the lab as in the wild — two very different environments.

Among transgenic mice on the experimental diets, the mice on the Fortasyn diet performed equally well as the wild - type mice, whereas other dietary treatments showed no improvement.

The immunological benefits from the wild mice's gut bacteria may, in part, explain a persistent problem in disease research: Why disease experiments in lab mice, such as vaccine studies, turn out very differently in humans or other animals.

A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of wild house mice — the same species as the lab mouse — shows that their immune state is promoted by individuals» body condition and constrained by their age.

IL - 15Rα — KO mice also produced a greater number of wheel revolutions than wild - type C57BL / 6 mice, as depicted by the dashed line in Figure 3B.

However, I did obtain a number of female Z116A transgenic mice that were heterozygous for the myostatin mutation, and as shown in Table 1 and Figure 2a, these mice exhibited further increases in muscle weights compared to Z116A mice that were wild type for myostatin.

It suggests that the early hunter - gatherer settlements transformed ecological interactions and food webs, allowing house mice that benefited from human settlements to out - compete wild mice and establish themselves as the dominant population.

As shown in Table 1, the presence of one or two Mstn mutant alleles in combination with the F66 transgene resulted in increasingly more muscle mass than seen in F66 transgenic mice that were wild type for Mstn.

«The competition between commensal house mice and other wild mice continued to fluctuate as humans became more mobile in arid periods and more sedentary at other times — indicating the sensitivity of local environments to degrees of human mobility and the complexity of human environmental relationships going back in the Pleistocene,» said Weissbrod, currently a research fellow at the Zinman Institute of Archaeology at the University of Haifa.

As shown in Table 1, all four lines exhibited significant increases in muscle weights compared to wild type control mice.

C57BL / 6 wild - type mice (The Jackson Laboratory, 000664; n = 8) were used as an additional control for comparison purposes, but were not included in any statistical analyses.

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

'' (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses)» - Michael

As it was the case among irradiated wild - type mice, the predominant tumors induced by radiation in p21 - null mice were T - cell lymphomas (Table 3) ⇓.

Perfusion of microvessels in Tie2PEKO mice was further confirmed by similar extent of hypoxic areas as compared to tumours growth in wild - type mice (Supplementary Fig. 12b).

And the claim typically persists for decades once widely - cited, despite the best efforts of serious investigators to critique weak methodologies and flawed interpretation, or even robust demonstrations of a null effect in healthy animals (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses).»

For comparison, we have also followed in parallel a colony of 30 wild - type mice of the same genetic background as the p21 - null mice (i.e., C57BL6 / 129Sv 50:50).

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

Methods: R6 / 2 CAG 240 (peak training at 11 weeks of age), zQ175 knock in (KI) HET (peak training at 27 weeks of age) and BAC HD (peak training at 48 weeks of age), as well as respective age - matched wild type (WT) control mice, were trained on the peak interval task (20 s interval) in which response rates during unreinforced peak trials were examined.

Analysis of fecal proteins revealed a reduced trypsin amount in the 5xFAD model mice as compared to the wild type.

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

Those mice were unsuccessful with context fear conditioning, but they did as well as wild - type mice when they were treated with memantine.

Wild - type littermates were used as controls for Grn + / − and Grn − / − mice.

As is described in further detail in the revised manuscript, we estimate that a 30 % increase in progranulin is the change required to bring an average Grn + / - mouse within 2 standard deviations of wild - type levels, making this a reasonable estimate for a biologically significant increase.

Wild type mice, such as the C57BL / 6 mouse, are relatively resistant to atherosclerosis, but have the capacity to develop mild atherosclerosis under certain conditions.

LOF mutations were defined as nonsense, frameshift, and splice - site variants, along with missense variants resulting in < 25 % of wild - type ANGPTL3 activity in a mouse model.

The Effect of Acetyl - L - carnitine and R - alpha - lipoic acid Treatment in ApoE4 Mouse as a Model of Human Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiography.

As the dangerous cat - and - mouse game unfolds, a wild card emerges: Madaline (Academy Award winner Jodie Foster), a power broker with a hidden agenda.

Leptospirosis is a contagious bacterial disease carried by wild animals such as deer, raccoons, mice, and cows.

It's closer to what a cat would get in the wild, especially if you feed small whole prey foods such as chicks or mice.

In the wild, dogs and cats consume small prey whole (such as moles, voles and mice), but eat selectively from larger prey, sometimes leaving the stomach and entrails behind.

Think about what a cat in the wild would eat, such as birds, mice and other small rodents, all of which are approximately 70 - percent water.

In the wild, hedgehogs eat a diverse selection of insects as well as some plant material and very occasionally small or baby mammals (like pinkie mice).

The mouse did everything I needed it to, whether I was blocking incoming fire as D.Va in Overwatch or fistfighting for money in The Witcher 3: Wild Hunt.