Researchers aware of this reality have now shown that transplanting gut bacteria from
wild mice into «clean» lab mice has made those rodents less likely to die from the flu or develop cancer.
Not exact matches
The researchers then transplanted the gut bacteria from healthy,
wild Maryland
mice (which were most similar genetically to the lab
mice)
into the lab
mice.
Looking further
into the intestinal crypts of both the transgenic and
wild - type
mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.
Probing the link between adiponectin deficiency and metabolic disorders like diabetes and obesity, researchers from the Albert Einstein College of Medicine in New York City injected adiponectin
into wild - type
mice, diabetic
mice, and obese diabetic
mice.
For prevention studies, they injected
mouse α - syn synthetic preformed fibrils
into wild - type, normal
mice, as a control, and then immediately treated the
mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control
mice).
The researchers followed up with two experiments: in one, they injected vasopressin
into the brains of
mouse parents from both of the
wild species, and in the other, they genetically manipulated vasopressin neurons in the brains of house
mice (Mus musculus) to excite them.
Instead of using the traditional method of introducing genetic mutations
into mice to create «knockout»
mice — or animals with customized genes — they found they were able to find naturally occurring variants among animals in the
wild.
This was further demonstrated by observing a rescue in metastatic efficiency by injecting POSTN - deficient tumor cells
into wild - type recipient
mice (Malanchi et al., 2012).
To circumvent this delay, scientists inject cattle tissue
into «
wild - type,» or normal,
mice to see if they develop the disease.
Interestingly, when parental d42m1 sarcoma cells were transplanted
into wild - type
mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).
The fluorescent labeling permitted the authors to monitor tumor outgrowth in vivo after mixtures were injected
into either
wild - type or Rag2 - knockout (immune system deficient)
mice.
When transplanted
into wild - type
mice with intact immune systems, these tumors are eliminated, presumably by T - cells.
The baboon quantitative genetics research spun off
into a quantitative genetic analysis of dental variation in
wild type
mice, finding a conserved pattern of genetic modularity (Molecular and Developmental Evolution, 2011, vol 316B: 21 - 49).
Both obese humans and
mice have significantly elevated soluble Fabp4 / aP2 levels, and injection of recombinant Fabp4 / aP2
into lean
wild type
mice stimulates hepatic glucose production and gluconeogenesis.
Transplantation of
wild - type and AMPK — / — bone marrow
into wild - type
mice revealed no difference in caffeine challenged reendothelialization.
Since the
mice do carry hantavirus, some basic precautions should be taken: do not feed any
wild animals; keep food and drink in rodent - proof containers; and prevent entry of
mice into your tent by keeping it zipped up at all times.