Now, a new study of
wild mice shows that they, too, can develop signs of domestication — white fur patches and short snouts — with hardly any human influence.
Not exact matches
This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to
show that an engineered skin graft can survive long term in
wild - type
mice with intact immune systems.
Researchers aware of this reality have now
shown that transplanting gut bacteria from
wild mice into «clean» lab
mice has made those rodents less likely to die from the flu or develop cancer.
When other scientists tried to repeat the maze trials that
showed a difference between the
wild and humanized
mice, however, they, too, found no difference in learning abilities.
The treatment was
shown to improve long - term memory performance of APP / PS1 and
wild - type
mice.
Next, they
showed that deer
mice and oldfield
mice build the same kinds of burrows in the lab as in the
wild — two very different environments.
Among transgenic
mice on the experimental diets, the
mice on the Fortasyn diet performed equally well as the
wild - type
mice, whereas other dietary treatments
showed no improvement.
The
wild - type
mice didn't develop colitis, but
showed low - grade inflammation in their intestines and several features of metabolic syndrome: slight weight gain, increased body fat and food intake, and higher blood sugar levels, which indicate poor glucose regulation associated with diabetes.
A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of
wild house
mice — the same species as the lab
mouse —
shows that their immune state is promoted by individuals» body condition and constrained by their age.
A team led by parasitologist Stefan Kappe at the Center for Infectious Disease Research in Seattle in Washington gave a rodent version of this «genetically attenuated parasite,» or GAP, to
mice and
showed that they were completely protected when later infected with an unmodified — or
wild - type — version of the same Plasmodium strain.
However, I did obtain a number of female Z116A transgenic
mice that were heterozygous for the myostatin mutation, and as
shown in Table 1 and Figure 2a, these
mice exhibited further increases in muscle weights compared to Z116A
mice that were
wild type for myostatin.
Numbers represent percent increases relative to
wild type
mice and were calculated from the data
shown in Table 1.
As
shown in Table 1, the presence of one or two Mstn mutant alleles in combination with the F66 transgene resulted in increasingly more muscle mass than seen in F66 transgenic
mice that were
wild type for Mstn.
As
shown in Table 1, all four lines exhibited significant increases in muscle weights compared to
wild type control
mice.
Histopathological examination of rejected corneal allografts in CD4 KO
mice revealed a mixed inflammatory infiltrate containing large numbers of neutrophils and mononuclear cells, which was indistinguishable from the infiltrate seen in rejected corneal allografts in
wild - type
mice (data not
shown).
Additionally, diabetic
mice genetically modified to lack PKal
showed far less retinal blood vessel leakage than
wild - type
mice.
As a control, irradiation of
wild - type
mice resulted in 100 % mortality after a period of 9 months after irradiation, when the
mice were 11 months old (Fig. 3 ⇓
shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.
Given that our
wild type B. burgdorferi acquired by xenodiagnostic ticks retain the ability to express ospC (also
shown by RT - PCR in Fig 4), we can not rule out the possibility that a tick midgut - adapted phenotype, in the absence of salivation and feeding, contributed to the failure of the B. burgdorferi acquired from XT to infect SCID
mice.
We
show that PC1 is ubiquitously and incompletely cleaved in
wild - type
mice, so that uncleaved and cleaved PC1 molecules coexist.
The next slide actually
shows you one of the slides from this publication,
showing you that this is the
wild - type
mice; males on the left and females on the right.
Greater running distance in the 2 - to 3 - month - old
mice may partially explain these data, but the solo - housed
wild - type
mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young
mice, yet did not
show any increase in brain progranulin levels.
mice show significant increase in relative and absolute hepatic weight compared to
wild - type; otherwise, no differences from
wild - type are noted
Consistent with this finding, enumeration of annexin V + DCs and active Caspase - 3 + DCs in spleen cell suspensions failed to
show differences in their frequency in
wild - type and EBI2 - deficient
mice (not
shown).
A very neat paper
shows that transgenic
mice made to overexpress a certain hormone live much longer than
wild type
mice: The starvation hormone, fibroblast growth factor - 21, extends lifespan in
mice.
A very neat paper
shows that transgenic
mice made to overexpress a certain hormone live much longer than
wild -LSB-...]