Sentences with phrase «wild type b»

Activated, wild type B cells from female mice tightly localize Xist RNA at their inactive X chromosomes (left), whereas Xist RNA becomes dispersed throughout the entire nucleus when YY1 is deleted (right).

Not exact matches

At least in part to deal with such points, Eigen more recently pointed out that each biological genome is not a single sequence of bases on DNA (a unique «point in sequence space») but rather a fairly large number of variant sequences that have quite similar — even indistinguishable — biological functions.11 b, 11 c Most of these functionally similar sequences differ from the «wild - type» sequence in only one or a few locations, but some have fairly large discrepancies.

Panel b: Disease - related Rumi mutations abolish the enzyme's activity relative to the «wild type» (WT) unmutated enzyme, likely leading to compromised Notch signaling and pathogenesis.

Overall, the cytochrome B knock - out strain is much less virulent, and mice infected with it survive much longer than those with the wild - type strain.

Compared with wild - type embryos (A), uninjected alk8 — / — embryos are weakly (class 2; C2) dorsalized (B), with loss of the ventral fin fold (arrowheads).

B: Microscopic images of wild - type and gosh mutant retinas at 3 months - post-fertilization.

(B) Transverse section of a stage 41 wild - type retina.

By tagging wild type and mutant constructs of ATP7B with Green Fluorescent Protein (GFP), we have followed the copper - dependent dynamics of the protein in polarized WIF - B cells.

For experiments requiring complete eye field replacement (A and B), one half of the eye field was surgically removed from wild - type, stage 15 (host) embryos, and replaced with the donor cells from one half of an explant.

Liliana M.; El - Khodor B F.; Hornberger M.; Park, Larry; Howland, David; Brunner D. Effect of the rd1 mutation on motor performance in R6 / 2 and wild type mice [Internet].

(B) Compared with wild - type A10.1 (left), bsl1 - 1 (right) and bsl1 - 2 (middle) mutant panicles are skinnier and have reduced bristle phenotypes.

(B) One proposed model for bristle versus spikelet differentiation in a wild - type S. viridis inflorescence depends on a diffusible factor that enhances spatiotemporal accumulation of BRs.

(A) and (B) At 14 DAS, Bsl1 mRNAs were localized to the base of primary branches (white arrow; [A]-RRB- and lateral organ boundaries (red arrow) of higher order BMs in A10.1 wild - type inflorescences (B).

Radiation - induced thymic lymphomas from a wild - type mouse (A) and from a p21 - deficient mouse (B).

Deletion of DGKζ or Cbl - b comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cellsb comparably enhanced CD8 + T cell functional responses, such as proliferation, production of IFN - γ, and generation of granzyme B when compared with wild type T cellsB when compared with wild type T cells.

We observed that Erk phosphorylation was modestly enhanced in Cbl - b − / − CD8 + T cells when compared with wild type (WT) T cells but was greatly enhanced in DGKζ − / − and DKO CD8 + T cells when compared either with Cbl - b − / − or WT CD8 + T cells (Fig. 1A).

Figure 2: Representative histology images of A: wild type and B: Tg197 animals at 7 weeks of age depicting the symptoms of Infiltration of inflammatory cells, Synovial hyperplasia, Articular cartilage destruction and Bone erosions evident as Tg5453 arthritic pathology.

To complement the experimental data, we also performed MD simulations on the wild - type B. licheniformis, E. cloacea (NMC - A), P. vulgaris (Bla - B), TEM - 1, ENCA, GNCAMP, GNCA4 and PNCA β - lactamases, as well as the corresponding GNCAMP - W229D, GNCA4 - W229D / F290W and PNCA - W229D variants (PDB IDs: 4BLM, 1BTL, 3ZDJ, 4B88, 5FQQ, 4C6Y, 4UHU, 5FQI respectively).

(A-D) Overexpressing GBP1 or GBP2 increases body size in wild - type females and males (A and B, respectively) at 25 °C or 22 °C (C and D, respectively).

(B and C) Western blot and immunofluoresence assay of Jurkat cells transfected with wild - type (WT), KMT2D mutants (V5486M)(B) and EP300 mutants (H1377R)(C) upon treatment with different HDAC inhibitors.

(A, B) Culturing wild - type brains with conditioned media from GBP1 and GBP2 expressing cells induces low level of ILP2 (A) and ILP5 (B) accumulation in the insulin - producing cells.

(B) Relative amounts of dilp3 mRNA in wild - type and CCHa2 - R mutant brains were quantified by RT - qPCR.

(A and B) Cuticle phenotype of embryos from wild - type and psqrum homozygous females.

(A — D) Immunostaining with an anti-Vas antibody in embryos from wild - type (A and B) and psqrum (C and D) females.

(B) The wild type male reproductive tract consists of a pair of oval - shape testes (white arrow head) attached to the epididymis (white arrow), seminal vesicle (yellow arrowhead), and urethra (yellow arrow).

Six weeks of wheel running (A) failed to increase frontal cortex progranulin mRNA (B) or hippocampal progranulin protein (C) in either solo - or group - housed wild - type mice aged 3 — 6 months.

(B) In wild - type cells, those highly active genes are tethered to centromeres, and chromatin loops derived from centromeres are supercoiled.

(A) In wild - type (wt; N2), UNC - 9:: GFP expressed in B motor neurons (Pacr - 5:: unc - 9:: gfp) visualizes puncta in the ventral nerve cord localized near B cell bodies.

In unc - 9 mutants, the brightest UNC - 9:: GFP puncta are still localized near B cell bodies, but more puncta are distributed elsewhere along the cord compared to wild - type (Figure 8C).

(B) Schematic representation of the pCMV - Neo-APC expression vector that codes the full - length APC sequence together with wild - type or mutated miR - 142 targeted site located at the 3 ′ UTR.

Despite being so sensational in parts the runtime hopscotches between a) surreal mix of «poignant & brilliant coming - of - age moments» (some of the most authentic - feeling «college girl» insights) and b) «handheld / realistic / hedonistic Girls - Gone - Wild - type shenanigans».