Sentences with phrase «wild type cd4»

Not exact matches

Further analysis showed that wild type HIV - 1 tends to integrate itself into or near genes affecting CD4 + T cell activation and metabolism more frequently than does the mutant strain.

To determine whether ZFN - mediated disruption of cxcr4 indeed protects CD4 + T cells from an in vitro HIV challenge, human CD4 + T cells from three different ccr5 wild type donors were stimulated and transduced with AdX4 - ZFNs or an AdR5 - ZFNs control.

Thus, treatment with X4 - ZFNs of both wild - type and ccr5Δ32 CD4 + T cells confers stable cxcr4 disruption and a marked survival advantage in the presence of R5X4 - HIV and X4 - HIV in vitro without any detectable effect on cell growth or viability in the absence of HIV.

A greater percentage of Themis - deficient T cells had CD4 + CD25 + Foxp3 + regulatory and CD62LloCD44hi memory phenotypes than did wild - type T cells.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Histopathological examination of rejected corneal allografts in CD4 KO mice revealed a mixed inflammatory infiltrate containing large numbers of neutrophils and mononuclear cells, which was indistinguishable from the infiltrate seen in rejected corneal allografts in wild - type mice (data not shown).

The results indicated that 54 % (38/70) of the BALB / c corneal allografts underwent rejection in the CD4 KO hosts, while 100 % of the grafts were rejected in wild - type C57BL / 6 mice (Figure 1).

In HeLa CD4 + cell assay this virus has an IC50 value for ddI and ddC around 6 - 10 fold that of the wild type parental virus HXB2.

In HeLa CD4 + cell assay this virus has an IC50 value for 3TC and FTC around 1000 fold that of the wild type parental virus HXB2.

In HeLa CD4 + cell assay this virus has an IC50 value for AZT around 60 - 70 fold that of the wild type parental virus HXB2.

MEFs from Brctx - deficient embryos grow at a similar rate to wild - type MEF CD4 / CD8 expressions, and the cell cycle parameters of thymocytes from wild - type and Brctx knockout animals are indistinguishable.

Using both wild - type and immunocompromised mice, we hope to elucidate the role of dengue - specific CD8 + and CD4 + T - cells against Zika.