In HeLa CD4 + cell assay this virus has an IC50 value for AZT around 60 - 70 fold that of
the wild type parental virus HXB2.
In HeLa CD4 + cell assay this virus has an IC50 value for 3TC and FTC around 1000 fold that of
the wild type parental virus HXB2.
In HeLa CD4 + cell assay this virus has an IC50 value for ddI and ddC around 6 - 10 fold that of
the wild type parental virus HXB2.
These are high passage
wild type parental clones suitable for DNA extraction, control purposes, but not for germline transmission.
Not exact matches
In these analyses, six of 90 F1 progeny (∼ 7 %) showed a distinct phenotype compared to the haploid
parental strain XL280 and the remaining 84 progeny showed no phenotypic differences from the
wild -
type (Figure 3A and Figure S3).
Phenotypic diversity is caused by this aneuploidy, as loss of the aneuploid chromosomes restored both euploidy and the
wild -
type parental phenotype.
The p21waf1 / cip1 promoter — driven luciferase reporters (pGL3 derivatives) containing point mutations in six Sp1 elements, (Mut1) p21 - Luc, (Mut2) p21 - Luc, (Mut3) p21 - Luc, (Mut4) p21 - Luc, and (Mut5 / 6) p21 - Luc and the
parental wild -
type reporter, (Wt) p21 - Luc, were kindly provided by Dr. D. Kardassis (Department of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece; ref.
Interestingly, when
parental d42m1 sarcoma cells were transplanted into
wild -
type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).
Notably, the regressor clones (T1, T2, T9) eliminated in
wild -
type mice were more closely related to the
parental tumor, whereas the progressor clones (T3, T10) were more closely related to the escape tumors.